分析胎龄<32周双胎早产儿血清25-羟基维生素D、维生素A和维生素E水平的表达特点及患儿预后情况  

Analysis of the expression characteristics of levels of 25-hydroxyvitamin D,vitamin A,and vitamin E in the serum of premature twins with gestational age<32 weeks and child patient prognosis

作　　者：张娟 董丽滨 张宇 ZHANG Juan;DONG Libin;ZHANG Yu(Department of Neonatology,the Second Affiliated Hospital of Mudanjiang Medical University,Heilongjiang,Mudanjiang 157000,China)

机构地区：[1]牡丹江医学院附属第二医院新生儿科,黑龙江牡丹江157000

出　　处：《中国医药科学》2024年第2期99-102,共4页China Medicine And Pharmacy

摘　　要：目的分析早产儿双胞胎(胎龄<32周)血清25-羟基维生素D、维生素A和维生素E水平的表达特征。方法选取牡丹江医学院附属第二医院2015年1月至2021年6月新生儿中的100例双胞胎早产儿接受研究,并按“胎龄大小”分为两组(每组各50例),对照组纳入50例胎龄≥32周,观察组纳入50例胎龄<32周,对两组进行血清25-羟基维生素D、维生素A和维生素E的检测,并比较两组检测结果和并发症发生率。结果观察组25-羟基维生素D[(19.32±6.91)nmol/L]、维生素A[(358.71±116.02)nmol/L]、维生素E[(450.25±174.25)nmol/L]低于对照组,差异有统计学意义(P<0.05);观察组新生儿呼吸窘迫综合征(RDS)、胎儿生长受限(FGR)、支气管肺发育不良(BPD)发病率高于对照组,差异有统计学意义(P<0.05),其他疾病之间的发病率,与对照组接近,差异无统计学意义(P>0.05);25-羟基维生素D缺乏患者的RDS和FGR较非维生素D缺乏的患者升高,差异有统计学意义(P<0.05)。结论胎龄<32周双胎早产儿血清25-羟基维生素D、维生素A和维生素E相对较低,且更易出现各种并发症,因此在生活中需加强管理及干预,通过合理补充维生素达到改善预后效果的目的。Objective To analyze the expression characteristics of levels of 25-hydroxyvitamin D,vitamin A,and vitamin E in the serum of premature twins(gestational age<32 weeks).Methods A total of 100 cases of premature twins admitted to the Department of Neonatology of the Second Affiliated Hospital of Mudanjiang Medical University from January 2015 to June 2021 were selected as the research objects.They were divided into two groups according to"gestational age"(50 cases in each group).50 cases of gestational age≥32 weeks were included in the control group,and 50 cases of gestational age<32 weeks were included in the observation group.25-hydroxyvitamin D,vitamin A,and vitamin E in the serum were tested in both groups.The test results and complication rates of the two groups were compared.Results The observation group had lower levels of 25-hydroxyvitamin D([19.32±6.91]nmol/L),vitamin A([358.71±116.02]nmol/L),and vitamin E([450.25±174.25]nmol/L)compared to the control group,with statistically significant differences(P<0.05).The incidence rate of neonatal respiratory distress syndrome(RDS),fetal growth restriction(FGR),bronchopulmonary dysplasia(BPD)in the observation group was higher than that in the control group,with statistically significant difference(P<0.05).The incidence rate of other diseases in the observation group was compared with that in the control group,without statistically significant difference(P>0.05).The incidence of RDS and FGR in patients with 25-hydroxyvitamin D deficiency was higher than that in patients without vitamin 25-hydroxyvitamin D deficiency,with statistically significant difference(P<0.05).The incidence of RDS,BPD,and FGR in patients with vitamin A deficiency was higher than that in in patients without vitamin A deficiency,with statistically significant difference(P<0.05).Conclusion Premature twins with gestational age<32 weeks have relatively low levels of 25-hydroxyvitamin D,vitamin A,and vitamin E in the serum,and are more prone to various complications.Therefore,it is necessary to s

关 键 词：胎龄 25-羟基维生素D 维生素A 维生素E 

分 类 号：R722.6[医药卫生—儿科]