治疗药物监测的文献计量学分析与临床实践  

Bibliometric analysis and clinical practice of therapeutic drug monitoring

作　　者：卢艳钦 曹畅 王路敏 叶岩荣 沈赟 LU Yanqin;CAO Chang;WANG Lumin;YE Yanrong;SHEN Yun(Department of Pharmacy,Zhongshan Hospital,Fudan University(Xiamen Branch),Fujian,Xiamen 361000,China)

机构地区：[1]复旦大学附属中山医院厦门医院药剂科,福建厦门361000

出　　处：《中国医药科学》2024年第2期126-129,共4页China Medicine And Pharmacy

基　　金：复旦大学附属中山医院厦门医院孵化课题(2020ZSXMYJ03)。

摘　　要：目的利用文献计量学方法分析国内外治疗药物监测领域热点和趋势,结合复旦大学附属中山医院厦门医院(本院)2022年开展的治疗药物监测情况进行回顾性分析,为促进临床合理用药提供参考。方法基于Web of Science核心数据库和中国知网(CNKI)使用CiteSpace软件对2019—2023年关于治疗药物监测领域的研究进行关键词的共现分析、聚类分析。结果筛选后纳入1301篇英文文献、330篇中文文献进行文献计量学分析。国内外研究中的高频关键词包括治疗药物监测的药物以及分析方法。2022年本院开展药物浓度检测总例数为864例。监测排名前三位的药物分别是他克莫司(37.27%)、雷帕霉素(18.17%)和万古霉素(14.35%)。他克莫司的治疗药物浓度结果处于有效浓度范围占比最高为90.06%,其次是雷帕霉素为85.35%,地高辛为85.00%。结论目前治疗药物监测研究主要为万古霉素、地高辛、抗癫痫药物的合理用药。本院搭建临床药师参与报告解读的治疗药物监测平台,还需关注抗精神类药物以及抗肿瘤药物的治疗药物监测。Objective To analyze the hotspots and trends in the field of therapeutic drug monitoring both domestically and internationally using bibliometric methods,and to conduct a retrospective analysis of the monitoring of therapeutic drugs conducted by Zhongshan Hospital,Fudan University(Xiamen Branch)(our hospital)in 2022,to provide a reference for promoting rational drug use in clinical practice.Methods Based on the Web of Science core database and China National Knowledge Infrastructure(CNKI),CiteSpace software was used to conduct keyword co-occurrence and aggregation analysis on research in the field of therapeutic drug monitoring from 2019 to 2023.Results After the screening,1301 English articles and 330 Chinese articles were included for bibliometric analysis.The high-frequency keywords in domestic and international researches include drugs for therapeutic drug monitoring and analysis methods.In 2022,our hospital conducted a total of 864 drug concentration tests.The top three drugs monitored were tacrolimus(37.27%),rapamycin(18.17%),and vancomycin(14.35%).The therapeutic drug concentration of tacrolimus was found to be within the effective concentration range,with the highest proportion being 90.06%,followed by 85.35% of rapamycin and 85.00% of digoxin.Conclusion Currently,research on therapeutic drug monitoring mainly focuses on the rational drug use of vancomycin,digoxin,and antiepileptic drugs.Our hospital has established a therapeutic drug monitoring platform for clinical pharmacists to participate in report interpretation,and more attention should be paid to the monitoring of antipsychotic drugs and anti-tumor drugs.

关 键 词：治疗药物监测 文献计量学 药物浓度 合理用药 

分 类 号：R96[医药卫生—药理学]