血清中PCT、α1酸性糖蛋白及触珠蛋白水平与急性期COPD病情严重程度的相关性  

The Correlation between Serum Levels of PCT,Acidic Glyceprotein and Heptoglobin and the Severity of Acute COPD

作　　者：王瑜 Wang Yu(Department of Respiratory Medicine,Xiangcheng First People's Hospital,Xiangcheng,Henan 466200)

机构地区：[1]项城市第一人民医院呼吸内科,河南项城466200

出　　处：《哈尔滨医药》2023年第6期4-6,共3页Harbin Medical Journal

摘　　要：目的 研究血清中PCT、α1酸性糖蛋白及触珠蛋白水平与急性期COPD病情严重程度的相关性。方法 将70例急性期COPD患者作为研究对象,按照疾病的严重程度分为COPD稳定期组34例和急性加重期(AECOPD)组36例,且选取同时间段来我院参加健康体检的40例志愿者作为对照组。使用酶联免疫吸附法检测血清α1酸性糖蛋白(α1-AG)水平,采用免疫荧光双抗体夹心法检测降钙素原(PCT)水平,通过免疫散射速率比浊法来测定血清触珠蛋白(HPT)水平,通过肺功能仪来测定用力肺活量(FVC)及第1秒用力呼气容积(FEV1)水平;采用Pearson分析肺功能指标与血清PCT、α1-AG、HPT的相关性。结果 COPD稳定期组、AECOPD组的血清PCT、α1-AG、HPT水平均高于对照组,且COPD患者血清PCT、α1-AG、HPT水平及肺功能指标FEV1、FEV1/FVC随疾病的严重程度呈上升趋势;COPD患者血清PCT、HPT与FEV1、FEV1/FVC均呈负相关,而α1-AG水平与FEV1%、FEV1/FVC均呈正相关,差异有统计学意义(P<0.05)。结论 血清PCT、α1-AG、HPT水平与COPD患者病情严重程度密切相关,对评估患者病情具有重要意义。Objective To study PCTα1 The correlation between the levels of acid glycoprotein and haptoglobin and the severity of acute COPD.Methods 70 patients with acute COPD were selected as the study subjects.According to the severity of the disease,they were divided into stable COPD group of 34 patients and acute exacerbation(AECOPD)group of 36 patients,and 40 volunteers who came to our hospital for health examination at the same time were selected as the control group.Detection of serum by enzyme-linked immunosorbent assayα1 Acid glycoprotein(α1-AG)level,the level of procalcitonin(PCT)was detected by immunofluorescence double antibody sandwich method,the level of serum haptoglobin(HPT)was measured by immune scattering rate turbidimetry,and the level of forced vital capacity(FVC)and forced expiratory volume in one second(FEV1)were measured by pulmonary function meter;Pearson was used to analyze pulmonary function indicators and serum PCTα1-Correlation of AG and HPT.Results Serum PCTα1-AG and HPT levels were higher than those in the control group,and serum PCTα1-AG,HPT levels and pulmonary function indicators FEV1,FEV1/FVC increased with the severity of the disease;Serum PCT and HPT were negatively correlated with FEV1 and FEV1/FVC in patients with COPD The level ofα1-AG was positively correlated with FEV1%and FEV1/FVC,and the difference was statistically significant(P<0.05).Conclusion Serum PCT The levels ofα1-AG and HPT are closely related to the severity of COPD patients,which is of great significance in evaluating the patients'condition.

关 键 词：COPD 降钙素原 Α1酸性糖蛋白 触珠蛋白 

分 类 号：R563[医药卫生—呼吸系统]