老年高尿酸血症患者同型半胱氨酸水平分析  

Analysis of homocysteine level in elderly patients with hyperuricemia

作　　者：沈静 许敏殷 石磊[3] SHEN Jing;XU Minyin;SHI Lei(Laboratory Department,Xiaodongmen Community Health Service Center,Huangpu District,Shanghai 200010;Laboratory Department,Shanghai Pulmonary Hospital,Shanghai 200438;Laboratory Department,Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海市黄浦区小东门街道社区卫生服务中心检验科,上海200010 [2]上海市肺科医院检验科,上海200438 [3]上海中医药大学附属曙光医院检验科,上海201203

出　　处：《临床医学研究与实践》2024年第5期47-50,共4页Clinical Research and Practice

基　　金：2019年上海市黄浦区科研项目(No.HKQ201921)。

摘　　要：目的 分析老年高尿酸血症患者的同型半胱氨酸(HCY)水平。方法 在2020年1月至2021年6月来上海市黄浦区小东门街道社区卫生服务中心进行免费体检的65岁以上老年人中,将确诊高尿酸血症的517例患者纳入观察组,200名健康者纳入对照组。比较两组研究对象的查体项目、生化指标及HCY水平。结果观察组的腰臀围比、体重指数、舒张压、收缩压均显著高于对照组,差异具有统计学意义(P<0.05);观察组组内比较,合并高脂血症和糖尿病患者的腰臀围比、体重指数、舒张压、收缩压均显著高于无合并症、合并高脂血症、合并糖尿病患者,差异具有统计学意义(P<0.05)。观察组的甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、肌酐(Cr)、空腹血糖(FBG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、尿酸(UA)、HCY水平均显著高于对照组,高密度脂蛋白胆固醇(HDL-C)水平显著低于对照组,差异具有统计学意义(P<0.05);观察组组内比较,合并高脂血症和糖尿病患者的TG、LDL-C、TC、Cr、FBG、FINS、HOMA-IR、UA、HCY水平均显著高于无合并症、合并高脂血症、合并糖尿病患者,HDL-C水平显著低于无合并症、合并高脂血症、合并糖尿病患者,差异具有统计学意义(P<0.05)。结论 老年高尿酸血症患者的HCY水平升高,而下调HCY水平可能降低高尿酸血症及其合并高脂血症、糖尿病患者发生脑血管意外的风险,值得临床充分重视。Objective To analyze the homocysteine(HCY)level in elderly patients with hyperuricemia.Methods Among the elderly over 65 years old who came to Xiaodongmen Community Health Service Center,Huangpu District in Shanghai for free physical examination from January 2020 to June 2021,517 patients diagnosed with hyperuricemia were included in observation group,and 200 healthy people were included in control group.The physical examination items,biochemical indexes and HCY level of the two groups were compared.Results The waist-hip ratio,body mass index,diastolic blood pressure and systolic blood pressure in the observation group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05);the comparison within the observation group showed that the waist-hip ratio,body mass index,diastolic blood pressure and systolic blood pressure in patients combined with hyperlipidemia and diabetes were significantly higher than those without complications,with hyperlipidemia and diabetes,and the differences were statistically significant(P<0.05).The levels of triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),total cholesterol(TC),creatinine(Cr),fasting blood glucose(FBG),fasting insulin(FINS),homeostatic model assessment of insulin resistance(HOMA-IR),uric acid(UA)and HCY in the observation group were significantly higher than those in the control group,while the level of high-density lipoprotein cholesterol(HDL-C)was significantly lower than that in the control group,and the differences were statistically significant(P<0.05);the comparison within the observation group showed that the levels of TG,LDL-C,TC,Cr,FBG,FINS,HOMA-IR,UA and HCY in patients combined with hyperlipidemia and diabetes were significantly higher than those in patients without complications,with hyperlipidemia and diabetes,the level of HDL-C was significantly lower than that in patients without complications,with hyperlipidemia and diabetes,and the differences were statistically significant(P<0.05).Conc

关 键 词：老年患者 高尿酸血症 同型半胱氨酸 尿酸 

分 类 号：R589.7[医药卫生—内分泌]