顺尔宁联合干扰素治疗呼吸道合胞病毒感染毛细支气管炎患儿的疗效及对炎症标志物的影响  

Efficacy of Singulair Combined with Interferon in the Treatment of Respiratory Syncytial Virus Bronchiolitis and Its Influence on Inflammatory Markers

作　　者：卢宜娟 卢军芳[1] 张科 Lu Yijuan;Lu Junfang;Zhang Ke(Department of Pediatrics,The Second People's Hospital of Anyang,Anyang 455000,China)

机构地区：[1]安阳市第二人民医院儿科,河南安阳455000

出　　处：《哈尔滨医药》2023年第5期29-31,共3页Harbin Medical Journal

摘　　要：目的 观察呼吸道合胞病毒(RSV)感染毛细支气管炎患儿采用顺尔宁治疗方案中联用干扰素(IFN)辅助治疗的效果及其对炎症标志物水平的影响。方法 选取60例RSV感染毛细支气管炎患儿病例,将其按照单双号法随机分成单一组和联合组各30例,单一组药物治疗仅采用顺尔宁,联合组则采用顺尔宁与IFN共同治疗。观察两组患儿临床治疗效果,用药7d后患儿咳嗽、喘息以及肺部喘鸣音、湿啰音的消退时间,比较治疗前后两组患儿炎症指标[半胱氨酸白三烯(leukotriene)、血清超敏C反应蛋白(hs-CRP)、白细胞介素-4(IL-4)、白细胞介素-8(IL-8)]水平变化,记录患儿用药后发生的不良反应情况。结果治疗7d后,联合组治疗有效率明显高于单一组,差异有统计学意义(P<0.05);联合组患儿咳嗽等不适症状的消退时间较单一组更短,差异有统计学意义(P<0.05);治疗前两组患儿炎症指标中CysLTs、hs-CRP、IL-4、IL-8水平差异无统计学意义(P>0.05)。治疗7d后,两组患儿血清CysLTs、hs-CRP、IL-4、IL-8水平较治疗前差异有统计学意义(P<0.05),且联合组较同一时间单一组下降更明显(P<0.05);两组患儿在治疗后发生的恶心、呕吐等不良反应情况比较,差异无统计学意义(P>0.05)。结论 RSV感染毛细支气管炎患儿应用顺尔宁联用IFN进行治疗可提升疗效,减轻呼吸道炎性水平,且药物方案安全性较好,适宜在临床推广应用。Objective To observe the effect of Singulair combined with interferon(IFN)on RSV bronchiolitis and its in-fluence on the level of inflammatory markers.Methods A total of 60 cases of RSV bronchiolitis were randomLy divided into single group and combined group according to odd-even number method,with 30 cases in each group.The single group was treated with Singulair,and the combination group was treated with Singulair and IFN.The clinical therapeutic effect of the two groups was observed,and the regression time of cough,wheezing,pulmonary wheezing sound and wet rales was observed 7 days after medication.The changes of inflammatory indexes(CysLTs,hs-CRP,IL-4,IL-8)before and after treatment were compared between the two groups,and the adverse reactions of the children after medication were recorded.Results After 7 days of treatment,the effective rate of the combined group was significantly higher than that of the single group(P<0.05).The regression time of cough and other discomfort in the combined group was shorter than that in the single group,and the dif-ference was significant(P<0.05).Before treatment,there were no significant differences in the levels of CysLTs,hs-CRP,IL-4 and IL-8 in the two groups(P>0.05).After 7 days of treatment,serum levels of CysLTs,hs-CRP,IL-4 and IL-8 in the two groups were significantly decreased compared with before treatment(P<0.05).The decrease of the combined group was more obvious than that of the single group at the same time(P<0.05).There was no significant difference in the adverse reactions such as nausea and vomiting between the two groups after treatment(P>0.05).Conclusions The treatment of RSV bronchi-olitis with Singulair combined with IFN can improve the curative effect,reduce the level of respiratory inflammation,and the medicines and ways are safe,which is suitable for clinical application.

关 键 词：顺尔宁 干扰素 呼吸道合胞病毒 毛细支气管炎 炎症标志物 

分 类 号：R562.21[医药卫生—呼吸系统]