桃核承气汤保留灌肠治疗在脓毒症肠功能障碍中的疗效观察  

The efficacy of Taohe Chengqi Decoction in the treatment of sepsis patients with intestinal dysfunction

作　　者：谢函谕 潘金龙 金永旭[1] 王立祥 李静 彭伟 方邦江[4] 刘婉嫣[1] Xie Hanyu;Pan Jinlong;Jin Yongzu;Wang Liriang;Li Jing;Peng Wei;FangBangjiang;Liu Wanyan(Jilin Hospital of Integrative Chinese and Western Medicine;Chinese Society of Research Hospitals;Beijing GMR Medical Equipment Company Ltd;Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,China)

机构地区：[1]吉林省吉林中西医结合医院重症医学科 [2]中国研究型医院学会心肺复苏专业委员会 [3]北京德美瑞医疗设备有限公司 [4]上海中医药大学附属龙华医院

出　　处：《实用休克杂志（中英文）》2023年第5期273-277,共5页Journal of Practical Shock

摘　　要：目的观察桃核承气汤保留灌肠治疗在脓毒症肠功能障碍中的临床疗效。方法将60例脓毒症合并肠功能障碍患者分为治疗组及对照组,治疗组给予常规西医治疗合并桃核承气汤保留灌肠。对照组仅给予常规西医治疗。对比两组治疗前后疗效、APACHEⅡ评分、胃肠功能恢复情况、炎症指标(WBC、CRP、PCT)及28d病死率。结果治疗组总有效率高于对照组(P<0.05)。两组治疗前肠功能障碍评分、APACHEⅡ评分比较,差异无统计学意义(P>0.05);经过7d治疗后肠功能障碍评分、APACHEⅡ评分低于对照组(P<0.05)。两组治疗前白细胞计数、降钙素原、C-反应蛋白比较,差异无统计学意义(P>0.05);两组治疗后白细胞计数、降钙素原、C-反应蛋白较前明显改善(P<0.05),两组28d病死率无统计学意义。结论桃核承气汤灌肠治疗脓毒症肠功能障碍,可明显临床症状、肠功能障碍、急性生理和慢性健康状况以及白细胞计数、降钙素原、C-反应蛋白等炎症指标,疗效显著。Objective To observe the clinical efficacy of Taohe Chengqi Decoction in the treatment of sepsis patients with intestinal dysfunction.Methods A total of 60 patients with sepsis complicated with intestinal dysfunction were divided into treatment group and control group,and the treatment group was given conventional western medicine treatment combined with peach pit gas decoction retention enema.The control group was treated only with conventional western medicine.The efficacy,APACHEII score,gastrointestinal function recovery,inflammatory indexes(WBC,CRP,PCT)and 28-day mortality rate before and after treatment were compared between the two groups.Results The overall effective rate of the treatment group was higher than that of the control group(P<0.05).There was no statistically significant difference in the APACHEI score of intestinal dysfunction between the two groups before treatment(P>0.05),and the posterior tractal dysfunction score and APACHEII score after 7 days of treatment were lower than those in the control group(P<O.05).There was no significant difference in white blood cell count,procalcitonin and C-reactive protein between the two groups(P>0.05),and the white blood cell count,procalcitonin and C-reactive protein were significantly improved after treatment(P<0.05),and the 28-day mortality rate between the two groups was not statistically significant.Conclusions The enema of Taohe Chengqi Decoction in the treatment of sepsis intestinal dysfunction can show obvious clinical symptoms,intestinal dysfunction,acute physiological and chronic health conditions,white blood cell count,procalcitonin,C-reactive protein and other inflammatory indicators,and the curative effect is significant.

关 键 词：桃核承气汤 保留灌肠 脓毒症 肠功能障碍 临床观察 

分 类 号：R459.7[医药卫生—急诊医学]