铁死亡在缺血性脑损伤中的作用和机制  

Role and mechanism of ferroptosis in ischemic brain injury

作　　者：董梦琦 曹翔 徐运[1,2] Dong Mengqi;Cao Xiang;Xu Yun(Clinical Medical School of Drum Tower Hospital,Nanjing University,Nanjing 210008,China;Departmentof Neurology,the Drum Tower Hospital Affiliated to Nanjing University Medical School,Nanjing 210008,China)

机构地区：[1]南京医科大学鼓楼临床医学院,南京210008 [2]南京大学医学院附属鼓楼医院神经内科,南京210008

出　　处：《国际脑血管病杂志》2023年第9期711-716,共6页International Journal of Cerebrovascular Diseases

基　　金：国家自然科学基金(82130036,81920108017);科技创新2030-脑科学与类脑研究重大项目(2022ZD0211800)。

摘　　要：铁死亡是近年发现的一种以铁依赖和脂质氢过氧化物过度蓄积为主要特征的细胞死亡方式,其调控机制主要涉及铁代谢、脂质过氧化反应和氨基酸代谢。铁死亡与缺血性卒中的发病机制密切相关,是缺血性卒中的一个有前途的治疗靶点。文章阐述了铁死亡的主要调控通路在缺血性卒中中的作用,为靶向铁死亡通路改善缺血性卒中转归提供了新的治疗思路和靶点。Ferroptosis is a cell death mode characterized by iron-dependent and excessive accumulation of lipid hydroperoxides,which has been discovered in recent years.Its regulatory mechanisms mainly involve iron metabolism,lipid peroxidation and amino acid metabolism.Ferroptosis is closely associated with the pathogenesis of ischemic stroke and is a promising therapeutic target for ischemic stroke.This article elaborates on the role of the main regulatory pathways of ferroptosis in ischemic stroke,providing new therapeutic ideas and targets for targeting the ferroptosis pathway to improve the outcome of ischemic stroke.

关 键 词：缺血性卒中 脑缺血 铁死亡 信号转导 

分 类 号：R651.15[医药卫生—外科学]