红簕钩中1个新的齐墩果烷型降三萜  

A new nor-oleanane triterpenoid from Rubus pirifolicus

作　　者：陈文娇 宁小燕 黄美芳 卢澄生 梁臣艳[1,2,3] 冯旭 韦建华[1,3] 王柳萍 CHEN Wenjiao;NING Xiaoyan;HUANG Meifang;LU Chengsheng;LIANG Chenyan;FENG Xu;WEI Jianhua;WANG Liuping(College of Pharmacy,Guangxi University of Chinese Medicine,Nanning 530200,China;Guangxi Superior Chinese Patent Medicine and National Medicine Development Engineering Technology Research Center,Nanning 530200,China;National Demonstration Center for Experimental Chinese Medicine Education,Guangxi University of Chinese Medicine,Nanning 530200,China)

机构地区：[1]广西中医药大学药学院,广西南宁530200 [2]广西优势中成药与民族药开发工程技术研究中心,广西南宁530200 [3]广西中医药大学中药学国家级实验教学示范中心,广西南宁530200

出　　处：《中草药》2024年第1期43-50,共8页Chinese Traditional and Herbal Drugs

基　　金：国家重点研究计划项目(2019YFC1712304);广西科技基地和人才专项(桂科AD20238058);广西中医药管理局科研课题(GXZYZ20210068);广西壮瑶药重点实验室项目(GXZYKF2022-16);广西中医药大学科研项目(2020ZD002);广西中医药大学研究生教育创新计划项目(YCXJ2021020);国家级大学生创新创业训练计划项目(202110600013)。

摘　　要：目的 研究红簕钩Rubus pirifolicus的化学成分。方法 采用大孔树脂、硅胶、ODS、Sephadex LH-20以及半制备HPLC等方法进行分离纯化,根据波谱数据并结合文献对化合物结构进行鉴定。结果 从红簕钩醋酸乙酯部位中分离得到16个化合物,分别鉴定为梨叶悬钩子酸A(1)、acanthochlamic acid(2)、2α,3β-dihydroxyolean-13(18)-en-28-oic acid(3)、3-表-2-氧代-坡模醇酸(4)、2α,3α,19α,22α-tetrahydroxyurs-12-en-28-oicacid(5)、23-O-galloylarjungenin(6)、2α,3α,19α,24-四羟基齐墩果-12-烯-28-羧酸(7)、bellericageninB(8)、roburgenicacid(9)、2β,3β,19α-三羟基齐墩果-12-烯-23,28-二羧酸(10)、2α,3β,23-trihydroxylup-20(29)-en-28-oicacid28-O-β-D-glucopyranoside(11)、熊果酸(12)、山楂酸(13)、科罗索酸(14)、坡模酸(15)、齐墩果酸(16)。结论 化合物1为新化合物,命名为梨叶悬钩子酸A,化合物2~3、5~6、8~10为首次从悬钩子属中分离得到,所有化合物均为首次从该植物中分离得到。Objective To study the chemical constituents from Rubus pirifolicus.Methods The extract from R.pirifolicus was isolated and purified by macroporous resin,silica gel column,ODS,Sephadex LH-20 and semi-preparative HPLC.Their structures were identified by spectral analysis combined with literature.Results Sixteen compounds were isolated from the ethyl acetate extracts of R.pirifolicus and identified as pirifoliusic acid A(1),acanthochlamic acid(2),2α,3β-dihydroxyolean-13(18)-en-28-oic acid(3),3-epi-2-oxopomolic acid(4),2α,3α,19α,22α-tetrahydroxyurs-12-en-28-oic acid(5),23-O-galloylarjungenin(6),2α,3α,19α,24-tetrahydroxyolean-12-en-28-oic acid(7),bellericagenin B(8),roburgenic acid(9),2β,3β,19α-trihydroxyolean-12-ene-23,28-dioic acid(10),2α,3β,23-trihydroxylup-20(29)-en-28-oic acid 28-O-β-D-glucopyranoside(11),ursolic acid(12),maslinic acid(13),corosolic acid(14),pomolic acid(15),oleanolic acid(16).Conclusion Compound 1 is a new compound and named pirifoliusic acid A;Compounds 2—3,5—6,8—10 were isolated from the Rubus for the first time,and all the compounds were isolated from this plant for the first time.

关 键 词：红簕钩 齐墩果烷型降三萜 梨叶悬钩子酸A acanthochlamic acid 2α 3β-dihydroxyolean-13(18)-en-28-oic acid 

分 类 号：R284.1[医药卫生—中药学]