柴胡防治精神神经疾病的共有物质基础及其生物学机制系统解析  

Systematic analysis of shared material basis and its biological mechanism for prevention and treatment of psychoneurological disorders by Bupleuri Radix

作　　者：冯渝梅 李惠珍 艾志福[1] 刘亚丽 杨明[1,4] 朱根华 陈丽玲[1] 苏丹[1] 宋永贵[1] FENG Yumei;LI Huizhen;AI Zhifu;LIU Yali;YANG Ming;ZHU Genhua;Chen Liling;SU Dan;SONG Yonggui(Key Laboratory of Depression Animal Model Based on TCM syndrome,Key Laboratory of Evaluation of Traditional Chinese Medicine Efficacy(Prevention and Treatment of Brain Disease with Mental Disorders),Nanchang 330103,China;Key Laboratory of Efficacy and Safety Evaluation,Health Commission of Jiangxi Province,Nanchang Medical College,Nanchang 330004,China;Key Laboratory of Pharmacology and Quality Evaluation of Chinese Herbal Medicines,Jiangxi Provincial Administration of Traditional Chinese Medicine,Nanchang 330004,China;Jiangxi Guxiang Jinyun Comprehensive Health Industry Co.,Ltd.,Nanchang 330004,China)

机构地区：[1]江西中医药大学抑郁症中医证候动物模型、中药药效(防治精神障碍脑疾病)评价江西省中医药管理局重点研究室,江西南昌330103 [2]南昌医学院药效与安全性评价江西省卫生健康委员会重点实验室,江西南昌330004 [3]江西省中医药管理局中草药药理学与质量评价重点实验室,江西南昌330004 [4]江西古香今韵大健康产业有限公司,江西南昌330004

出　　处：《中草药》2024年第1期307-319,共13页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(82074014);江西省自然科学基金资助项目(20224BAB216088);江西省教育厅科学技术研究项目(GJJ201239,GJJ2200979);江西中医药大学博士科研启动基金(2022BSZR014)。

摘　　要：柴胡Bupleuri Radix是传统中医疏肝解郁要药,临床上不仅用于抑郁症的治疗,在焦虑、癫痫、阿尔茨海默病和帕金森等多种精神神经疾病防治中也广泛应用。然而精神、神经疾病常互相伴发,给临床用药造成困扰,最近的研究提出二者可能存在共同的神经生物学基础。因此在梳理柴胡对抑郁、焦虑、阿尔茨海默病等优势病种的基础上,对柴胡防治精神神经疾病的共同物质基础及共有机制进行系统解析,为寻找柴胡在精神神经疾病防治方面的作用规律提供思路,推动柴胡在该作用方面的深入理解和后续的研发,也为探究传统中医药“异病同治”的治疗原则提供科学依据。Chaihu(Bupleuri Radix),a traditional Chinese medicine,is not only used in the treatment of depression,but also in prevention and treatment of anxiety,epilepsy,Alzheimer’s disease,Parkinson’s disease and other psychoneurological disorders.However,psychiatric and neurological disorders often coexist,posing challenges for clinical pharmacotherapy.Recent studies have suggested that there may be a common neurobiological basis for both.Therefore,this paper provides a systematic analysis of the common material basis and common mechanism of Bupleuri Radix in prevention and treatment of psychoneurological disorders based on the combing of the dominant diseases such as depression,anxiety and Alzheimer’s disease,in order to provide an idea for the search of the action pattern of Bupleuri Radix in prevention and treatment of psychoneurological disorders,to promote the in-depth understanding and subsequent research and development of Bupleuri Radix in this action, and to provide a scientific basis for the investigation of the treatment principle of “homotherapy for heteropathy” in traditional Chinese medicine.

关 键 词：柴胡 共有物质基础 精神神经疾病 焦虑 癫痫 阿尔茨海默病 帕金森 异病同治 

分 类 号：R285[医药卫生—中药学]