铁死亡调控机制及其在心血管疾病中的研究进展  

Ferroptosis homeostasis regulation and its research progress in cardiovascular diseases

作　　者：马赛[1] 左庆娟 和丽丽[2] 张国瑞[3] 郭艺芳[2] Ma Sai;Zuo Qingjuan;He Lili;Zhang Guorui;Guo Yifang(Department of Pain,Hebei General Hospital,Shijiazhuang 050051,China;Ward 1,Department of Geriatric Cardiology,Hebei General Hospital,Shijiazhuang 050051,China;Department of Cardiology,The Third Hospital of Shijiazhuang,Shijiazhuang 050011,China)

机构地区：[1]河北省人民医院疼痛科,石家庄050051 [2]河北省人民医院老年心血管内一科,石家庄050051 [3]石家庄市第三医院心血管内科,050011

出　　处：《中国心血管杂志》2023年第6期568-573,共6页Chinese Journal of Cardiovascular Medicine

基　　金：河北省创新能力提升计划项目(199776249D);河北省重点研发计划项目(19277787D)。

摘　　要：铁死亡是一种近期发现的可调节的程序性细胞坏死方式,涉及铁代谢、脂质代谢、氨基酸代谢等多种代谢过程,其主要特征为脂质过氧化物生成、活性氧超载和谷胱甘肽消耗等。研究证实铁死亡参与了多种心血管疾病病理生理过程。本文总结了铁死亡调控机制及国内外关于铁死亡在心血管疾病中的研究进展,旨在为心血管疾病的预防和治疗提供新思路。Ferroptosis is a recently discovered regulated form of programmed cell death,involving various metabolic processes such as iron metabolism,lipid metabolism,and amino acid metabolism.Its main features include lipid peroxide generation,oxidative stress,and glutathione depletion.Studies have confirmed the involvement of ferroptosis in various pathophysiological processes of cardiovascular diseases.This article summarizes the regulatory mechanisms of ferroptosis and the research progress on ferroptosis in cardiovascular diseases both domestically and internationally,aiming to provide new insights for the prevention and treatment of cardiovascular diseases.

关 键 词：铁死亡 心力衰竭 心肌病 心血管疾病 

分 类 号：R54[医药卫生—心血管疾病]