高原肺动脉高压研究进展  

Research progress in high-altitude pulmonary hypertension

作　　者：王嘉琦 李为昊 陈玉成[1] Wang Jiaqi;Li Weihao;Chen Yucheng(Department of Cardiology,West China Hospital,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院心脏内科,成都610041

出　　处：《中国心血管杂志》2023年第6期601-606,共6页Chinese Journal of Cardiovascular Medicine

基　　金：四川省科技厅重点研发项目(2019YFQ0004)。

摘　　要：高原肺动脉高压由高原低压低氧的特殊环境引起,是高原定居人群和流动人群生命健康的重要威胁。高原肺动脉高压的发病与基因和环境相关,其发生发展的主要机制为低氧性肺血管收缩和重构,目前研究显示可能与交感神经系统兴奋、一氧化氮生成减少、内皮素1的合成增加、单磷酸腺苷活化蛋白激酶激活和胞质游离钙离子浓度升高等有关。本文就高原肺动脉高压的研究历史及研究进展进行综述。High-altitude pulmonary hypertension is caused by the unique environment of low pressure and low oxygen at high altitudes,posing a significant threat to the health and well-being of both permanent and temporary residents in high-altitude areas.The development of high-altitude pulmonary hypertension is influenced by both genetic and environmental factors,with the main mechanisms being hypoxia-induced pulmonary vasoconstriction and remodeling.Current research suggests that it may also be associated with sympathetic nervous system activation,reduced nitric oxide production,increased endothelin-1 synthesis,activation of adenosine monophosphate-activated protein kinase,and elevated cytoplasmic free calcium ion concentration.This article provides a comprehensive review of the research history and progress in the field of high-altitude pulmonary hypertension.

关 键 词：高原 肺高压 流行病学 发病机制 治疗 

分 类 号：R544.1[医药卫生—心血管疾病]