绝经后骨质疏松患者血清DPP-4、UA、P、25(OH)D_(3)水平变化及其与骨代谢指标的相关性  

Changes of serum DPP-4,UA,P,25(OH)D_(3) levels and their correlation with bone metabolism indexes in patients with postmenopausal osteoporosis

作　　者：殷小红 李亚[1] 马卫国[1] 白晶晶 YIN Xiao-hong;LI Ya;MA Wei-guo;BAI Jing-jing(Department of Endocrinology,the First Affiliated Hospital of Xi'an Medical University,Xi'an 710000,Shaanxi,CHINA;Department of Spinal Surgery,Xi'an Traditional Chinese Medicine Hospital,Xi'an 710000,Shaanxi,CHINA)

机构地区：[1]西安医学院第一附属医院内分泌科,陕西西安710000 [2]西安市中医医院脊柱外科,陕西西安710000

出　　处：《海南医学》2024年第3期372-375,共4页Hainan Medical Journal

基　　金：陕西省西安市2020年市级中医药科研项目(编号:SZL202021)。

摘　　要：目的检测绝经后骨质疏松患者血清二肽基肽酶-4(DPP-4)、尿酸(UA)、孕酮(P)、25羟维生素D_(3)[25(OH)D_(3)]水平,并分析其与骨代谢指标的相关性。方法选择2022年2月至2023年2月西安医学院第一附属医院收治的320例绝经后骨质疏松患者作为观察组,并选择同期在我院接受体检的300名健康绝经女性作为对照组,比较两组受检者的血清DPP-4、UA、P、25(OH)D_(3)水平及骨代谢指标[骨钙素(OC)、I型前胶原氨基末端前肽(PINP)、β-胶联降解产物(β-CTX)及骨碱性磷酸酶(BALP)],并采用Pearson法分析血清DPP-4、UA、P、25(OH)D_(3)水平与骨代谢指标的相关性。结果观察组患者的血清DPP-4水平为(183.41±21.49)IU/L,明显高于对照组的(125.82±13.04)IU/L,UA、P、25(OH)D_(3)水平分别为(252.83±21.69)μmol/L、(1.23±0.18)nmol/L、(21.21±3.72)ng/mL,明显低于对照组的(304.34±25.77)μmol/L、(1.70±0.22)nmol/L、(32.74±3.51)ng/mL,差异均有统计学意义(P<0.05);观察组患者OC、PINP、β-CTX、BALP分别为(8.02±1.18)μg/L、(225.34±34.02)ng/mL、(0.75±0.09)ng/mL、(21.76±3.05)μg/L,明显高于对照组的(5.57±0.84)μg/L、(175.06±26.71)ng/mL、(0.45±0.06)ng/mL、(15.80±2.43)μg/L,差异均有统计学意义(P<0.05);经Pearson相关性分析结果显示,血清DPP-4与OC、PINP、β-CTX、BALP均呈正相关(P<0.05),UA、P、25(OH)D_(3)与OC、PINP、β-CTX、BALP均呈负相关(P<0.05)。结论绝经后骨质疏松患者血清DPP-4水平升高,UA、P、25(OH)D_(3)水平降低,且均与骨代谢指标具有明显相关性,临床上应予以密切关注。Objective To detect the serum dipeptidyl peptidase-4(DPP-4),uric acid(UA),progesterone(P),and 25 hydroxyvitamin D_(3)[25(OH)D_(3)]levels in patients with postmenopausal osteoporosis,and to analyze the correlation between them and bone metabolism indexes.Methods A total of 320 patients with postmenopausal osteoporosis admitted to the First Affiliated Hospital of Xi'an Medical College from February 2022 to February 2023 were selected as the observation group,and 300 healthy menopausal women who underwent physical examination in our hospital during the same period were selected as the control group.The serum DPP-4,UA,P,25(OH)D_(3) levels and bone metabolism indexes[osteocalcin(OC),amino terminal propeptide(PINP),β-CTX,and bone alkaline phosphatase(BALP)]of the two groups were compared,and the correlation between serum DPP-4,UA,P,25(OH)D_(3) levels and bone metabolism indexes was analyzed by Pearson method.Results The serum DPP-4 level in the observation group was(183.41±21.49)IU/L,which was significantly higher than(125.82±13.04)IU/L in the control group;the UA,P,and 25(OH)D_(3) levels were(252.83±21.69)μmol/L,(1.23±0.18)nmol/L,and(21.21±3.72)ng/mL,which were significantly lower than(304.34±25.77)μmol/L,(1.70±0.22)nmol/L,(32.74±3.51)ng/mL in the control group;the difference were statistically significant(P<0.05).The OC,PINP,β-CTX,and BALP in the observation group were(8.02±1.18)μg/L,(225.34±34.02)ng/mL,(0.75±0.09)ng/mL,and(21.76±3.05)μg/L,which were significantly higher than(5.57±0.84)μg/L,(175.06±26.71)ng/mL,(0.45±0.06)ng/mL,(15.80±2.43)μg/L in the control group(P<0.05).Pearson correlation analysis showed that serum DPP-4 was positively correlated with OC,PINP,β-CTX,and BALP,while UA,P,25(OH)D_(3) were negatively correlated with OC,PINP,β-CTX,and BALP(P<0.05).Conclusion Serum DPP-4 levels increased,and UA,P,25(OH)D_(3) levels decreased in patients with postmenopausal osteoporosis,and all of them are significantly correlated with bone metabolism indexes,which should be paid close attention

关 键 词：绝经 骨质疏松 二肽基肽酶-4 尿酸 孕酮 25羟维生素D_(3) 骨代谢 

分 类 号：R681.1[医药卫生—骨科学]