RSV感染致喘息发作患儿血清TARC表达水平与Th1和Th2细胞因子的相关性  

TARC expression and Th1 and Th2 cytokines in RSV-induced wheezing

作　　者：梅峻 孙敏 MEI Jun;SUN Min(Department of Pediatrics,Shanghai Dongfang Hospital,Shanghai 200123,CHINA)

机构地区：[1]上海市东方医院儿科,上海200123

出　　处：《海南医学》2024年第3期381-384,共4页Hainan Medical Journal

摘　　要：目的探讨呼吸道合胞病毒(RSV)感染致喘息发作患儿的血清胸腺活化调节趋化因子(TARC)的表达水平与1型辅助T细胞(Th1)和2型辅助T细胞(Th2)细胞因子的相关性。方法选取2021年5月至2022年10月上海市东方医院收治的200例感染性肺炎患儿(无既往支气管哮喘病史)作为研究对象,根据是否发生RSV感染将其分为非感染组86例和感染组114例。比较两组患儿喘息发生率和治疗结束随访6个月后的喘息复发率,检测并比较两组患儿急性期和恢复期血清中的TARC水平,并比较两组中复发患儿急性期血清中的Th1和Th2细胞因子水平,分析感染组复发患儿血清中TARC与Th1/2细胞因子的相关性。结果感染组患儿的喘息发生率和复发率分别为67.54%、58.77%,明显高于非感染组的34.88%、36.05%,差异均有统计学意义(P<0.05);在急性期,感染组未发生喘息和发生喘息的患儿血清中TARC水平分别为(336.17±68.65)g/L、(477.88±79.35)ng/L,明显高于非感染组的(297.81±58.92)ng/L、(386.33±63.79)ng/L,差异均有统计学意义(P<0.05);在恢复期,感染组发生喘息患儿血清中TARC水平为(364.89±62.15)ng/L,明显高于非感染组的(307.47±51.69)ng/L,差异有统计学意义(P<0.05),但两组中未发生喘息的患儿血清中TARC水平比较差异无统计学意义(P>0.05);在急性期和恢复期,感染组喘息首次发作和喘息复发患儿血清中TARC水平明显高于非感染组,且感染组喘息复发患儿急性期和恢复期的TARC水平明显高于喘息首次发作患儿,差异均有统计学意义(P<0.05);感染组复发患儿血清中Th2细胞因子白介素(IL)-4、IL-5和IL-13水平分别为(49.85±13.33)ng/L、(42.13±9.41)ng/L、(11.28±3.57)ng/L,明显高于非感染组复发患儿的(38.20±10.64)ng/L、(35.45±7.06)ng/L、(8.87±2.91)ng/L,差异均有统计学意义(P<0.05),但两组患儿血清中Th1细胞因子γ干扰素(IFN-γ)水平比较差异无统计学意义(P>0.05);感染组复发患儿血清中Objective To investigate the correlation between serum thymus and activation-regulated chemokine(TARC)expression level and helper T cell type 1(Th1)and helper T cell type 2(Th2)cytokines in children with respiratory syncytial virus(RSV)-induced wheezing.Methods A total of 200 children with infectious pneumonia(no previous history of bronchial asthma)admitted to Shanghai Dongfang Hospital from May 2021 to October 2022 were selected as the study objects.According to whether RSV infection occurred,the children were divided into a non-infected group(86 cases)and an infected group(114 cases).The incidence of wheezing at admission and after treatment were compared between the two groups,the serum TARC levels were detected and compared between the two groups at the acute stage and the recovery stage,and the serum Th1 and Th2 cytokines levels were compared between the two groups.The correlation between serum TARC and Th1/2 cytokines in children with recurrent infections in infected group was analyzed.Results The incidence of wheezing and recurrence rates in the infected group were 67.54%and 58.77%,which were significantly higher than 34.88%and 36.05%in the non-infected group(P<0.05).In the acute stage,the serum TARC levels in the infected group were(336.17±68.65)g/L and(477.88±79.35)ng/L,which were significantly higher than(297.81±58.92)ng/L and(386.33±63.79)ng/L in the non-infected group(P<0.05).In the recovery period,the serum TARC level in the infected group was(364.89±62.15)ng/L,which was significantly higher than(307.47±51.69)ng/L in the non-infected group(P<0.05),but there was no statistically significant difference in the serum TARC levels in children without wheezing between the two groups(P>0.05).In the acute stage and recovery stage,the serum TARC level in children with first onset and recurrence of wheezing in the infected group was significantly higher than that in the non-infected group,and the TARC level in the infected group in children with recurrence of wheezing was significantly higher than that i

关 键 词：喘息 呼吸道合胞病毒 胸腺活化调节趋化因子 感染 复发 相关性 

分 类 号：R725.6[医药卫生—儿科]