血清CCL5及CC16水平联合检测对支气管哮喘患儿沙丁胺醇雾化吸入治疗疗效的预测价值  

Predictive value of combined detection of serum CCL5 and CC16 levels on the efficacy of salbutamol aerosol inhalation in children with bronchial asthma

作　　者：刘丹 鲁旭 LIU Dan;LU Xu(Department of Pediatrics,Xianyang Central Hospital,Xianyang,Shaanxi 712000,China;Department of Neonatology,Xianyang Central Hospital,Xianyang,Shaanxi 712000,China)

机构地区：[1]咸阳市中心医院儿科,陕西咸阳712000 [2]咸阳市中心医院新生儿科,陕西咸阳712000

出　　处：《检验医学与临床》2024年第4期520-523,529,共5页Laboratory Medicine and Clinic

摘　　要：目的探讨血清趋化因子配体5(CCL5)、Clara细胞分泌蛋白16(CC16)水平检测对支气管哮喘(BA)患儿沙丁胺醇雾化吸入治疗疗效的预测价值。方法选择2019年10月至2022年10月该院收治的急性发作期BA患儿207例为研究对象,所有BA患儿均给予常规治疗联合吸入用硫酸沙丁胺醇溶液雾化治疗4周,根据治疗效果分为有效组和无效组。采用酶联免疫吸附试验检测两组治疗前血清CCL5和CC16水平,比较两组临床资料,采用多因素Logistic回归分析沙丁胺醇雾化吸入治疗BA临床疗效的影响因素,采用受试者工作特征(ROC)曲线分析血清CCL5、CC16水平对沙丁胺醇雾化吸入治疗BA临床疗效的预测价值。结果治疗4周后,有效161例(有效组),无效46例(无效组)。有效组治疗前血清CCL5水平低于无效组,血清CC16水平高于无效组,差异均有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,血清CCL5水平升高是沙丁胺醇雾化吸入治疗BA患儿临床有效的独立危险因素(P<0.05),而哮喘控制测试评分、呼气峰值流速、血清CC16水平升高是其保护因素(P<0.05)。血清CCL5、CC16单独及联合检测预测沙丁胺醇雾化吸入治疗BA临床疗效的曲线下面积(AUC)分别为0.798、0.868和0.930,联合检测的AUC大于单独检测(P<0.05)。结论血清CCL5水平升高是沙丁胺醇雾化吸入治疗BA患儿临床疗效的独立危险因素,血清CC16水平升高是其保护因素,二者联合检测能够较好地预测其临床疗效。Objective To investigate the predictive value of combined detection of serum chemokine ligand 5(CCL5)and Clara cell secretory protein 16(CC16)level in the treatment of albuterol aerosol inhalation in children with bronchial asthma(BA).Methods From October 2019 to October 2022,a total of 207 children with acute onset BA admitted to Xianyang Central Hospital were selected as the study subjects.All children with BA were given conventional treatment combined with inhaling salbutamol sulfate solution atomized inhalation for 4 weeks,and were divided into effective group and ineffective group according to the treatment effect.Enzyme linked immunosorbent assay was used to detect the serum CCL5 and CC16 levels of the two groups before treatment.The clinical data of the two groups were compared,and the factors influencing the clinical efficacy of salbutamol aerosol inhalation for BA were analyzed by multivariate Logistic regression.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum CCL5 and CC16 levels on the clinical efficacy of salbutamol aerosol inhalation therapy for BA.Results After 4 weeks of treatment,161 cases(effective group)were effective and 46 cases(ineffective group)were ineffective.Before treatment,the serum CCL5 level in the effective group was lower than that in the ineffective group,and the serum CC16 level was higher than that in the ineffective group,the differences were statistically significant(P<0.05).Multivariate Logistic regression analysis showed that the increase of serum CCL5 level was an independent risk factor for the clinical effectiveness of salbutamol aerosol inhalation in BA children(P<0.05),while the increase of Asthma Control Test score,peak expiratory flow rate and serum CC16 level were protective factors(P<0.05).The area under the curve(AUC)of the single and combined detection of serum CCL5 and CC16 to predict the clinical efficacy of salbutamol aerosol inhalation therapy for BA were 0.798,0.868 and 0.930 respectively.The AUC of the combined de

关 键 词：支气管哮喘 沙丁胺醇 趋化因子配体5 Clara细胞分泌蛋白16 预测 

分 类 号：R725.6[医药卫生—儿科]