基于数据挖掘探讨古今新安医家治疗乳腺癌用药规律  

Based on Data Mining to Explore the Medication Rules of Ancient and Modern Xin'an Doctors in the Treatment of Breast Cancer

作　　者：毛梦莹 曾永蕾[2] 郑欢欢 付莫骄 MAO Mengying;ZENG Yonglei;ZHENG Huanhuan;FU Mojiao(Anhui University of Chinese Medicine,Anhui Hefei 230012,China;The Second Affiliated Hospital of Anhui University of Chinese Medicine,Anhui Hefei 230061,China)

机构地区：[1]安徽中医药大学研究生院,安徽合肥230012 [2]安徽中医药大学第二附属医院,安徽合肥230061

出　　处：《中医药临床杂志》2024年第1期91-97,共7页Clinical Journal of Traditional Chinese Medicine

基　　金：安徽省高等学校科学研究项目(2022AH050527);安徽省省级中医发展专项经费项目曾永蕾名中医工作室(卫办秘[2020]10号);安徽省中医药传承创新科研项目(2020ccyb05)。

摘　　要：目的:基于数据挖掘技术探讨古今新安医家治疗乳腺癌的用药规律特色,为临床治疗乳腺癌类提供组方依据和思路。方法:收集古今新安医家医案医话中治疗乳腺癌的中医处方,利用WPS2019手工建立Excel中药数据库,应用SPSS Statistics 26.0及IBM SPSS Modeler 18.0进行聚类和关联分析。结果:严格按照纳入标准筛选处方50首,涉及中药124味,其中频次≥7次的药物共20味,以当归为首。药性以寒性为首,药味以苦味为首,归经以脾经为首。有效复方主要由清热药、补虚药、活血化瘀药等配伍而成。高频次药物组合包括甘草-人参、川芎-白芍、当归-人参&甘草等。结论:古今新安医家对乳腺癌的辨治颇有特色,以补为主,注重调补气血,固本培元,扶正与祛邪并重,为临床中医药治疗乳腺癌提供思路。Objective:Based on data mining technology,we explore the medication regularity and characteristics of Xin’an doctors in ancient and modern times in the treatment of breast cancer,and provide prescription basis and ideas for clinical treatment of breast cancer.Methods:Collecting traditional Chinese medicine prescriptions for the treatment of breast cancer from ancient and modern Xin’an medical records,use WPS2019 to manually establish an Excel Chinese medicine database,and use SPSS Statistics 26.0 and IBM SPSS Modeler 18.0 for clustering and correlation analysis.Results:50 prescriptions were screened strictly in accordance with the inclusion criteria,involving 124 traditional Chinese medicines,of which a total of 20 medicines were used≥7 times,led by Angelica sinensis.The medicinal properties are cold,the taste is bitter,and the spleen meridian is the primary meridian.The effective compound formula is mainly composed of heat-clearing drugs,deficiency-tonifying drugs,blood-activating and blood-stasisremoving drugs,etc.High-frequency drug combinations include licorice-ginseng,Ligusticum chuanxiong-white peony root,angelica-ginseng&licorice,etc.Conclusion:The diagnosis and treatment of breast cancer by Xin’an doctors in ancient and modern times is quite distinctive.It focuses on tonifying,focusing on regulating Qi and blood,consolidating the essence and strengthening the body,and paying equal attention to strengthening the body and eliminating evil.This provides ideas for the clinical treatment of breast cancer with traditional Chinese medicine.

关 键 词：数据挖掘 新安医家 乳腺癌 用药规律 

分 类 号：R273[医药卫生—中西医结合]