中药熏洗剂致皮肤不良反应的临床分析  

Clinical Analysis of Skin Adverse Reactions Caused by Traditional Chinese Medicine Fumigation Agents

作　　者：游正琴 高增杰 王俪瓯 汪石丽 宋红 覃裕 YOU Zheng-qin;GAO Zeng-jie;WANG Li-ou;WANG Shi-li;SONG Hong;QIN Yu(Inspection Center of Guizhou Provincial Drug Administration,Guiyang 550081,China;Department of Orthopedics,Guizhou Hospital of Beijing Jishuitan Hospital,Guiyang 550007,China;Department of Pharmacy,Guizhou Hospital of Beijing Jishuitan Hospital,Guiyang 550007,China)

机构地区：[1]贵州省药品监督管理局检查中心,贵阳550081 [2]北京积水潭医院贵州医院骨科,贵阳550007 [3]北京积水潭医院贵州医院药剂科,贵阳550007

出　　处：《中国合理用药探索》2024年第1期104-109,共6页Chinese Journal of Rational Drug Use

基　　金：贵州省卫生健康委科学技术基金项目(gzwkj2021-438);贵州省骨科医院创新基金项目(GZGYCX[2021]05号)。

摘　　要：目的:探讨中药熏洗剂致皮肤药品不良反应(ADR)的发生情况及临床表现,以期为临床安全合理使用中药熏洗剂提供参考。方法:回顾性分析2018年1月1日~2021年12月31日于某院骨内科5个治疗病区住院期间使用中药熏洗剂治疗的患者资料,分析ADR的发生情况、症状出现时间、临床表现及转归等,并提出预防措施。结果:该院骨内科5个治疗病区住院期间使用中药熏洗剂治疗的患者共2894例,其中75例(2.59%)患者发生了ADR,且女性患者高于男性患者。患者开始使用中药熏洗剂至出现ADR症状的最短时间为用药后6h,最长时间为用药第4天,中位时间为2.3天。出现单纯皮疹者31例,皮疹合并皮肤瘙痒者39例,皮肤破溃者5例,未发生严重ADR,经停用中药熏洗剂和对症处理后症状均缓解。结论:中药熏洗剂易引起皮肤ADR,在使用前医生应详细询问患者病情,筛选、排查发生过敏反应的潜在危险因素,并加强对中药熏洗剂致ADR的监测和预防。Objective:To investigate the occurrence and clinical manifestations of skin adverse drug reaction(ADR)caused by traditional Chinese medicine(TCM)fumigation agents,so as to provide reference for the safety and rational use of TCM fumigation agents in clinic.Methods:A retrospective analysis was conducted on the data of patients treated with TCM fumigation agents in 5 treatment wards of the department of osteology of a hospital from January 1,2018 to December 31,2021.The analysis focused on the occurrence,symptom onset time,clinical manifestations and outcomes of ADR,and proposed preventive measures.Results:A total of 2894 patients were treated with TCM fumigation agents during hospitalization in 5 treatment wards of the department of osteology.Among them,75 patients(2.59%)experienced ADR.The incidence of ADR in female patients was higher compared with male patients.The shortest time from the use of TCM fumigation agents to the occurrence of ADR symptoms was 6 hours after medication,the longest time was the 4 days after medication,with a median time of 2.3 days.There were 31 cases of simple rash,39 cases of rash accompanied by skin pruritus,and 5 cases of skin ulceration.No serious ADR occurred,and the symptoms were relieved after discontinuation of TCM fumigation agents and symptomatic treatment.Conclusion:TCM fumigation agents is prone to cause skin ADR.Prior to use,it is recommended that doctors conducts a detailed inquiry into the patient's condition,screen and investigate potential risk factors for allergic reactions,and enhance the monitoring and prevention of ADR caused by TCM fumigation agents.

关 键 词：中药熏洗剂 皮肤不良反应 安全用药警戒 中药安全性 临床分析 

分 类 号：R969.3[医药卫生—药理学]