集束化护理模式对肿瘤患者骨髓抑制期有效性的Meta分析  

Meta-analysis of the effectiveness of the cluster nursing model on myelosuppression in cancer patients

作　　者：李成成 殷利 向明芳 张萱 吕俭霞 LI Chengcheng;YIN Li;XIANG Mingfang;ZHANG Xuan;LV Jianxia(Sichuan Cancer Hospital,Chengdu 610041,China)

机构地区：[1]四川省肿瘤医院/四川省癌症防治中心/电子科技大学医学院,四川省成都市610041

出　　处：《护理实践与研究》2024年第2期240-248,共9页Nursing Practice and Research

基　　金：2022年四川省省级临床重点专科建设项目(编号:YB2022009)。

摘　　要：目的系统评价集束化护理对肿瘤患者骨髓抑制的效果。方法检索国内外中英文数据库,纳入有关集束化护理干预对骨髓抑制效果的随机对照试验(RCT),对文献进行质量评价,本研究采用RevMan 5.4统计软件进行数据分析。结果共纳入25篇RCT,其中中文23篇,英文2篇,共2072例患者。Meta分析结果显示,试验组(集束化护理措施)降低感染的发生率为RR=0.43,95%CI:0.36~0.50,P<0.00001;出血发生率RR=0.33,95%CI:0.24~0.46,P<0.00001;发热发生率RR=0.54,95%CI:0.44~0.67,P<0.00001;改善患者心理状态焦虑水平MD=-2.88,95%CI:-3.65~-2.11,P<0.00001;抑郁水平MD=-1.49,95%CI:-12.06~-0.92,P<0.00001以及提高患者满意度RR=1.25,95%CI:1.15~1.35,P<0.00001,均高于对照组,组间比较差异有统计学意义(P<0.05)。结论集束化护理可以预防肿瘤患者骨髓抑制期并发症的发生,同时改善患者心理状态,提高患者的满意度。Objective To systematically evaluate the effect of cluster nursing on myelosuppression in cancer patients.Methods We searched Chinese and English databases at home and abroad,included randomized controlled trials(RCT)on the effect of cluster nursing intervention on myelosuppression,and evaluated the quality of the literature.This study used RevMan 5.4 statistical software for data analysis.Results A total of 25 RCT were included,including 23 Chinese and 2 English,with a total of 2,072 patients.The Meta-analysis results showed that in the experimental group(cluster nursing measures),the incidence rate of infection was reduced by RR=0.43,95%CI:0.36~0.50,P<0.00001;the incidence rate of bleeding was RR=0.33,95%CI:0.24~0.46,P<0.00001;the incidence rate of fever was RR=0.54,95%CI:0.44~0.67,P<0.00001;the patient's psychological state,anxiety level,MD=-2.88,95%CI:-3.65~-2.11,P<0.00001,and depression level,MD=-1.49,95%CI:-12.06~-0.92,P<0.00001,and improved patient satisfaction RR=1.25,95%CI:1.15~1.35,P<0.00001,both higher than the control group,and the differences between the groups were statistically significant(P<0.05).Conclusion Cluster nursing can prevent the occurrence of complications in the myelosuppression phase of cancer patients,while improving the patient's psychological state and improving patient satisfaction.

关 键 词：肿瘤 骨髓抑制 集束化护理 有效性 META分析 

分 类 号：R47[医药卫生—护理学]