不同处方扶正辟邪颗粒药效学初探  

Preliminary Study on Pharmacodynamics of Fuzheng Bixie Granules with Different Prescriptions

作　　者：任桂林 杜仕静 谭正怀[2] 任维 罗群 蒲清荣 熊静悦[2] 毕涛 杨露银 杨思进 REN Guilin;DU Shijing;TAN Zhenghuai;REN Wei;LUO Qun;PU Qingrong;XIONG Jingyue;BI Tao;YANG Luyin;YANG Sijin(The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University,Luzhou,Sichuan,China 646000;Sichuan Academy of Chinese Medicine Sciences,Chengdu,Sichuan,China 610041;Institute of Integrated Traditional Chinese and Western Medicine,Southwest Medical University,Luzhou,Sichuan,China 646000)

机构地区：[1]西南医科大学附属中医医院,四川泸州646000 [2]四川省中医药科学院,四川成都610041 [3]西南医科大学中西医结合研究所,四川泸州646000

出　　处：《中国药业》2024年第4期43-46,共4页China Pharmaceuticals

基　　金：四川省中医药管理局项目[2021XYCZ006];西南医科大学-西南医科大学附属中医医院联合项目[2020XYLH-004]。

摘　　要：目的初步探讨不同处方扶正辟邪颗粒的药效学。方法制得不含与含挥发油的样品A与样品B。采用最大给药量法观察2种样品对小鼠的急性毒性作用。采用二甲苯致小鼠耳肿胀模型、环磷酰胺致小鼠免疫力低下模型及脂多糖致大鼠发热模型分别观察2种样品的抗炎、免疫调节及解热作用。结果各组小鼠体质量均自然增大,不同样品组小鼠体质量及主要脏器系数与对照组比较均无显著变化(P>0.05)。3个模型检测结果依次为,2种样品低剂量组小鼠耳肿胀度均显著低于模型1组(P<0.05);各给药组小鼠耳肿胀度与模型2组比较均无显著改变(P>0.05);样品A低剂量组大鼠腹腔注射脂多糖后3.0 h,样品B低剂量组0.5 h、1.0 h、3.0 h及样品B高剂量组1.0 h时大鼠肛温变化值与模型3组比较,差异均有统计学意义(P<0.05)。结论扶正辟邪颗粒具有抗炎、调节免疫力、解热等药效学作用。与单用浸膏比较,加入挥发油的处方药效更强。Objective To investigate preliminarily the pharmacodynamics of Fuzheng Bixie Granules with different prescriptions.Methods The sample A without volatile oils and sample B with volatile oils were prepared.The acute toxic effects of the above two samples on mice were observed by the maximum dose method.The anti-inflammatory,immunomodulatory and antipyretic effects of the above two samples were explored by the xylene-induced ear swelling model in mice,cyclophosphamide-induced hypoimmunity model in mice,and lipopolysaccharide(LPS)-induced fever model in rats,respectively.Results The body weight of mice in each group increased naturally,the body weight and major organ coefficients in different sample groups were similar to those in the control group(P>0.05).The results of three model tests were as follows:the ear swelling degree of mice in the samples A and B low-dose groups was significantly lower than that in the model group one(P<0.05);the ear swelling degree in the all groups with drugs was similar to that in the model group two(P>0.05);the anal temperature change after mtraperitoneal injection of LPS for 3.0 h in the sample A low-dose group,after mtraperitoneal injection of LPS for 0.5 h,1.0 h and 3.0 h in the sample B low-dose group and after mtraperitoneal injection of LPS for 1.0 h in the sample B high-dose group was significantly different from that in the model group three(P<0.05).Conclusion Fuzheng Bixie Granules have anti-inflammatory,immunomodulatory and antipyretic pharmacological effects.Compared with the prescriptions with only extracts,the prescriptions with extracts and volatile oils are more effective.

关 键 词：扶正辟邪颗粒 挥发油 急性毒性试验 抗炎 免疫调节 解热 提取工艺 

分 类 号：R965[医药卫生—药理学] R285[医药卫生—药学]