卡前列素氨丁三醇致大面积红斑1例及文献分析  

Large-Area Erythema Induced by Carboprost Tromethamine:A Case Report and Literature Analysis

作　　者：孙海宁 曹建英[3] 苏秀贞[4] SUN Haining;CAO Jianying;SU Xiuzhen(College of Traditional Chinese Medicine,Weifang Medical University,Weifang,Shandong,China 261053;Qingzhou Rongjun Hospital,Weifang,Shandong,China 262550;Weifang Maternal and Child Health Care Hospital,Weifang,Shandong,China 261011;Weifang Hospital of Tradi-tional Chinese Medicine,Weifang,Shandong,China 261041)

机构地区：[1]潍坊医学院中医学院,山东潍坊261053 [2]山东省青州荣军医院,山东潍坊262550 [3]山东省潍坊市妇幼保健院,山东潍坊261011 [4]山东省潍坊市中医院,山东潍坊261041

出　　处：《中国药业》2024年第4期125-128,I0001,共5页China Pharmaceuticals

基　　金：山东省妇幼保健协会科研项目。

摘　　要：目的为临床安全使用卡前列素氨丁三醇注射液提供参考。方法回顾性分析潍坊市妇幼保健院收治的1例肌肉注射卡前列素氨丁三醇注射液致注射部位大面积(26 cm×25 cm)红斑药品不良反应(ADR)的案例,并结合文献分析其发生原因。结果患者出现的注射部位大面积红斑与使用卡前列素氨丁三醇的因果关系为“很可能相关”(Naranjo量表评分为8分)。文献显示,该ADR可能与药品因素(辅料苯甲醇及成分氨丁三醇)、给药方式(肌肉注射)及个体差异[高龄(>30岁)、肥胖(体质量>70 kg)、顺产]等有关。结论该ADR属该药新的ADR,临床应加强用药安全监测及风险识别,保障患者安全用药。Objective To provide a reference for the safe use of Carboprost Tromethamine Injection in clinical practice.Methods The treatment process of a case of large-area erythema(26 cm×25 cm)at the administration site induced by intramuscular injection of Carboprost Tromethamine Injection admitted to the Weifang Maternal and Child Health Care Hospital was analyzed retrospectively.The causes of this adverse drug reaction(ADR)were explored based on literature analysis.Results The causal relationship between the occurrence of large-area erythema at the injection site and the use of carboprost tromethamine was"probable"(the score of Naranjo's ADR evaluation scale was eight points).Literature showed that this ADR might be related to the drug factors[benzyl alcohol(excipient)and tromethamine(main component)],administration method(intramuscular injection)and individual differences[advanced age(>30 years),obesity(body weight>70 kg),spontaneous delivery)].Conclusion Large-area erythema is a new ADR of Carboprost Tromethamine Injection.Medication safety monitoring and risk identification should be strengthened in clinical practice to ensure the safe drug use for patients.

关 键 词：卡前列素氨丁三醇注射液 大面积红斑 药品不良反应 安全用药 文献分析 

分 类 号：R969.3[医药卫生—药理学]