分析冠心病不稳定型心绞痛心电图改变患者应用丹参多酚酸盐联合心脉通胶囊治疗的临床价值  

Analysis of the clinical value of salvianolate combined with Xinmaitong capsule in the treatment of patients with unstable angina pectoris of coronary heart disease with electrocardiogram changes

作　　者：张鑫 肖宁 ZHANG Xin;XIAO Ning(Electrocardiogram Room,Yanggu County People's Hospital,Liaocheng 252300,China)

机构地区：[1]阳谷县人民医院心电图室,252300 [2]阳谷县人民医院心内科,252300

出　　处：《中国实用医药》2024年第3期10-14,共5页China Practical Medicine

摘　　要：目的探讨冠心病不稳定型心绞痛心电图改变患者应用丹参多酚酸盐联合心脉通胶囊治疗的价值。方法选择本院收治的80例冠心病不稳定型心绞痛心电图改变患者为本次研究对象,采用随机数字表法分为观察组及对照组,均40例。对照组予以常规药物治疗,包括营养心肌、扩血管、抗血小板、抗凝,同时应用丹参多酚酸盐治疗;观察组在对照组基础上应用心脉通胶囊治疗。比较两组患者的治疗效果,治疗前后的斑块稳定性[即血清脂蛋白相关磷脂酶A2(Lp-PLA2)]、左心室功能指标[左室射血分数(LVEF)、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)]、血脂指标(总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇)水平,不良反应发生情况。结果观察组治疗总有效率高于对照组,其中对照组治疗总有效率为80.00%,观察组为95.00%,差异显著(χ^(2)=4.114,P=0.043<0.05)。较治疗前,治疗后两组患者Lp-PLA2均降低,观察组(20.76±3.93)μg/L低于对照组的(36.34±4.42)μg/L,差异显著(P<0.05)。较治疗前,治疗后两组患者的LVEF水平均升高,观察组(49.89±3.07)%高于对照组的(46.26±3.22)%;LVEDD、LVESD水平均减小,观察组(51.83±3.66)、(35.87±3.41)mm小于对照组的(56.28±3.78)、(39.72±3.30)mm,差异显著(P<0.05)。较治疗前,治疗后两组患者的总胆固醇、甘油三酯、低密度脂蛋白胆固醇水平均降低,观察组(5.22±1.04)、(1.57±0.08)、(3.02±1.46)mmol/L低于对照组的(5.79±1.43)、(2.24±0.23)、(4.23±1.07)mmol/L;高密度脂蛋白胆固醇水平均升高,观察组(1.40±0.29)mmol/L高于对照组的(0.99±0.05)mmol/L,差异显著(P<0.05)。对照组不良反应发生率为5.00%,观察组为7.50%,两组比较无显著差异(χ^(2)=0.213,P=0.644>0.05)。结论冠心病不稳定型心绞痛心电图改变患者联合应用丹参多酚酸盐和心脉通胶囊治疗的效果突出,不仅利于改善斑块稳定性,而且可改善�Objective To explore the therapeutic value of salvianolate combined with Xinmaitong capsule in the treatment of patients with unstable angina pectoris of coronary heart disease with electrocardiogram changes.Methods 80 patients with unstable angina pectoris of coronary heart disease with electrocardiogram changes were selected as the subjects of this study.They were randomly divided into an observation group and a control group using a number table method,with 40 cases in each group.The control group was treated with conventional drugs,including myocardial nutrition,vasodilation,antiplatelet therapy,anticoagulation,and the use of salvianolate.The observation group was treated with Xinmaitong capsules on the basis of the control group.Both groups were compared in terms of treatment effect,plaque stability[i.e.,serum lipoprotein-associated phospholipase A2(Lp-PLA2)],left ventricular function indicators[left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD)],and lipid indicators(total cholesterol,triglycerides,low density lipoprotein cholesterol,high density lipoprotein cholesterol)before and after treatment,and the occurrence of adverse reactions.Results The total effective rate of the observation group was higher than that of the control group,with a total effective rate of 80.00%in the control group and 95.00%in the observation group,with a significant difference(χ^(2)=4.114,P=0.043<0.05).Compared with that before treatment,Lp-PLA2 in both groups decreased after treatment,and the LP-PLA2 of(20.76±3.93)µg/L in the observation group was lower than(36.34±4.42)µg/L in the control group,with a significant difference(P<0.05).Compared with those before treatment,LVEF levels in both groups were increased after treatment,and the observation group[(49.89±3.07)%]was higher than the control group[(46.26±3.22)%];the levels of LVEDD and LVESD decreased,and the levels of the observation group were(51.83±3.66)and(35.87±3.41)mm,which were lowe

关 键 词：不稳定型心绞痛 冠心病 心电图改变 丹参多酚酸盐 心脉通胶囊 

分 类 号：R541.4[医药卫生—心血管疾病]