激光联合干扰素治疗对阴道上皮内瘤变患者阴道微生态、炎症因子及预后的影响  

Effects of laser combined with interferon on vaginal microecology,inflammatory factors and prognosis in patients with vaginal intraepithelial neoplasia

作　　者：薛巧梅[1] XUE Qiao-mei(Department of Gynecology,Weihai Municipal Second Hospital Affiliated to Qingdao University,Weihai 264200,China)

机构地区：[1]青岛大学附属威海市立第二医院妇科,264200

出　　处：《中国实用医药》2024年第3期108-111,共4页China Practical Medicine

摘　　要：目的分析激光联合干扰素对阴道上皮内瘤变(VAIN)患者的阴道微生态、炎症因子以及预后的影响。方法60例VAIN患者,按随机数字表法分为对照组和研究组,每组30例。对照组患者通过二氧化碳(CO_(2))激光治疗,研究组患者通过CO_(2)激光联合干扰素治疗。比较两组患者临床治疗效果;并发症发生情况;治疗前后炎症因子指标[肿瘤坏死因子-α(TNF-α)、白细胞介素-10(IL-10)、Toll样受体2(TLR2)];生存素(Survivin)、增殖细胞核抗原(Ki-67)阳性表达情况。结果研究组患者的临床治疗总有效率96.67%高于对照组的73.33%,差异有统计学意义(P<0.05)。治疗后,研究组患者的TNF-α(9.66±0.43)ng/L、IL-10(8.83±0.54)ng/L、TLR2(6.31±0.29)ng/L均低于对照组的(12.09±0.78)、(10.79±1.36)、(7.95±0.46)ng/L,差异有统计学意义(P<0.05)。治疗后,研究组患者Survivin阳性表达率(24.45±2.97)%、Ki-67阳性表达率(20.71±2.49)%低于对照组的(36.21±3.96)、(40.58±3.83)%,差异有统计学意义(P<0.05)。研究组并发症发生率为6.67%(2/30),与对照组的10.00%(3/30)比较,差异无统计学意义(P>0.05)。结论针对VAIN患者给予VAIN患者激光联合干扰素治疗的临床效果更佳,能够有效改善炎症因子指标及Survivin、Ki-67表达情况,减少患者并发症的发生,值得推广应用。Objective To analyze the effects of laser combined with interferon on vaginal microecology,inflammatory factors and prognosis in patients with vaginal intraepithelial neoplasia(VAIN).Methods 60 VAIN patients were divided into a control group and a study group according to random number table method,with 30 cases in each group.The control group was treated with carbon dioxide(CO_(2))laser,and the study group was treated with CO_(2)laser combined with interferon.Both groups were compared in terms of clinical therapeutic effect,occurrence of complications,inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-10(IL-10),Toll-like receptor 2(TLR2)]before and after treatment,positive expression of Survivin and(Ki-67).Results The total effective rate of 96.67%in the study group was higher than 73.33%in the control group,and the difference was statistically significant(P<0.05).After treatment,the study group had TNF-αof(9.66±0.43)ng/L,IL-10 of(8.83±0.54)ng/L and TLR2 of(6.31±0.29)ng/L,which were lower than(12.09±0.78),(10.79±1.36)and(7.95±0.46)ng/L in the control group.The difference was statistically significant(P<0.05).After treatment,the Survivin positive expression rate in the study group was(24.45±2.97)%and Ki-67 positive expression rate was(20.71±2.49)%,which were lower than(36.21±3.96)and(40.58±3.83)%in the control group,and the difference was statistically significant(P<0.05).The incidence of complications in the study group was 6.67%(2/30),and there was no statistically significant compared with 10.00%(3/30)in the control group(P>0.05).Conclusion In VAIN patients,laser combined with interferon therapy has better clinical effect,which can effectively improve inflammatory factor indicators,the expression of Survivin and Ki-67,and reduce the occurrence of complications in patients,which is worthy of promotion and application.

关 键 词：激光 干扰素 阴道上皮内瘤变 阴道微生态 炎症因子 

分 类 号：R711[医药卫生—妇产科学]