益生菌对尘螨过敏性变应性鼻炎儿童的症状、药物使用及生活质量的影响  

The effect of probiotics on symptoms,medication use,and quality of life in children with dust mite allergic rhinitis

作　　者：容嘉妍[1] 黄娟[1] 王冰洁[1] 李德庚[1] 魏可英 刘翔腾[1] 陈昂[1] 林嘉镖[1] RONG Jia-yan;HUANG Juan;WANG Bing-jie(Department of Pediatrics,Boai Hospital of Zhongshan City,Zhongshan 528400,China)

机构地区：[1]广东省中山市博爱医院儿科,528400

出　　处：《中国实用医药》2024年第3期119-122,共4页China Practical Medicine

基　　金：2020年度中山市第一批社会公益与基础研究项目(医疗卫生)(项目编号:2020B1047)。

摘　　要：目的探讨益生菌对尘螨过敏性变应性鼻炎(AR)患儿的症状、药物使用及生活质量的影响。方法招募115例尘螨过敏性AR患儿作为研究对象,根据治疗方案的不同分为常规组(58例)和益生菌组(57例)。常规组采用常规治疗,益生菌组在常规组基础上给予益生菌干预。比较两组不同时间点[治疗前(T0)、治疗6个月后(T1)、停药6个月后(T2)]主观感受视觉模拟评分法(VAS)评分、用药评分、标准化鼻结膜炎生活质量调查问卷(RQLQ)评分、鼻部症状评分。结果常规组T0时VAS评分、用药评分、RQLQ评分分别为(5.97±2.01)、(1.64±1.06)、(2.04±0.72)分,T1时分别为(2.79±1.07)、(0.71±0.44)、(1.69±0.93)分,T2时分别为(2.48±0.99)、(0.58±0.49)、(1.71±0.93)分;益生菌组T0时VAS评分、用药评分、RQLQ评分分别为(6.18±1.94)、(1.71±1.09)、(2.01±0.73)分,T1时分别为(2.05±0.78)、(0.49±0.45)、(1.37±0.67)分,T2时分别为(2.21±0.81)、(0.54±0.45)、(1.58±0.72)分。两组T1和T2时VAS评分、用药评分、RQLQ评分均较T0时降低,益生菌组T1时VAS评分、用药评分、RQLQ评分均低于常规组,差异有统计学意义(P<0.05);T0、T2时两组VAS评分、用药评分、RQLQ评分无明显差异(P>0.05)。常规组T0时鼻塞、鼻痒、喷嚏、流涕评分分别为(1.81±0.66)、(1.60±0.62)、(1.68±0.77)、(1.34±0.69)分,T1时分别为(0.95±0.53)、(0.87±0.49)、(0.90±0.56)、(0.96±0.46)分,T2时分别为(0.93±0.54)、(0.84±0.43)、(0.88±0.31)、(0.89±0.54)分;益生菌组T0时鼻塞、鼻痒、喷嚏、流涕评分分别为(1.78±0.57)、(1.63±0.61)、(1.70±0.70)、(1.41±0.69)分,T1时分别为(0.75±0.45)、(0.72±0.23)、(0.70±0.43)、(0.78±0.50)分,T2时分别为(0.91±0.43)、(0.83±0.51)、(0.86±0.53)、(0.85±0.50)分;两组T1和T2时鼻塞、鼻痒、喷嚏、流涕评分均较T0时降低,益生菌组T1时低于常规组,差异有统计学意义(P<0.05);T0、T2时两组鼻塞、鼻痒、喷嚏、流涕评分无明显差异(P>0.0Objective To investigate the effect of probiotics on symptoms,medication use,and quality of life in children with dust mite allergic rhinitis(AR).Methods A total of 115 child patients with allergic AR caused by dust mites as study subjects were divided into the conventional group(58 cases)and the probiotic group(57 cases)according to different treatment methods.The conventional group was treated with conventional intervention,while the probiotic group was treated with probiotics on the basis of the conventional group.The subjective visual analogue scale(VAS)score,medication score,and rhinoconjunctivitis quality of life questionnaire(RQLQ)score,and nasal symptom score of the two groups of children were compared at different time points[before treatment(T0),6 months after treatment(T1),and 6 months after discontinuation of medication(T2)].Results At T0,the VAS score,medication score,and RQLQ score of the conventional group were(5.97±2.01),(1.64±1.06),and(2.04±0.72)points,respectively;at T1,they were(2.79±1.07),(0.71±0.44),and(1.69±0.93)points,respectively;at T2,they were(2.48±0.99),(0.58±0.49),and(1.71±0.93)points,respectively.At T0,the VAS score,medication score,and RQLQ score of the probiotic group were(6.18±1.94),(1.71±1.09),and(2.01±0.73)points,respectively;at T1,they were(2.05±0.78),(0.49±0.45),and(1.37±0.67)points,respectively;at T2,they were(2.21±0.81),(0.54±0.45),and(1.58±0.72)points,respectively.The VAS score,medication score and RQLQ score at T1 and T2 of the two groups were lower than those at T0;and the VAS score,medication score and RQLQ score at T1 of the probiotic group were lower than those of the conventional group;the difference was statistically significant(P<0.05).There were no significant differences in the VAS score,medication score and RQLQ score between the two groups at T0 and T2(P>0.05).At T0,the scores for nasal congestion,nasal itching,sneezing,and runny nose in the conventional group were(1.81±0.66),(1.60±0.62),(1.68±0.77),and(1.34±0.69)points,respectively;at T1,th

关 键 词：益生菌 尘螨过敏 变应性鼻炎 儿童 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]