基于肠道菌群及“脏腑别通理论”探讨肝脾同调治疗非酒精性脂肪性肝病的理论内涵  

Discussion on the Theoretical Connotation of Co-regulation of Liver and Spleen in Treatment of Non-alcoholic Fatty Liver Disease Based on Intestinal Flora and"Zangfu Bietong Theory"

作　　者：宗春晓 夏永良[2] 汤菲菲 田璐璐 王采奕 窦晓兵[1] ZONG Chunxiao;XIA Yongliang;TANG Feifei;TIAN Lulu;WANG Caiyi;DOU Xiaobing(School of Life Sciences,Zhejiang Chinese Medical University/Zhejiang Chinese Medical University Institute of Molecular Medicine,Hangzhou Zhejiang 310053,China;The First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou Zhejiang 310006,China;School of Public Health,Zhejiang Chinese Medical University,Hangzhou Zhejiang 310053,China)

机构地区：[1]浙江中医药大学生命科学学院/浙江中医药大学分子医学研究所,浙江杭州310053 [2]浙江中医药大学附属第一医院,浙江杭州310006 [3]浙江中医药大学公共卫生学院,浙江杭州310053

出　　处：《中医药导报》2024年第1期161-164,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(81773981)。

摘　　要：非酒精性脂肪性肝病的发生发展受肠道菌群的影响。肝脾同调治法可通过调节气机升降、水谷运化、血液运行以改善非酒精性脂肪性肝病,中医脏腑别通理论认为“肝与大肠相通”“脾与小肠相通”。通过论述肝脾二脏与肠道菌群、非酒精性脂肪肝之间的相关性,丰富肝脾同调治疗非酒精性脂肪性肝病的理论内涵,确立疏肝健脾、运脾清肝两大治疗原则,为中医诊治非酒精性脂肪肝提供新思路。The occurrence and development of non-alcoholic fatty liver disease are influenced by the gut microbiota.The co-regulation of liver and spleen therapy can improve non-alcoholic fatty liver disease by regulating the rise and fall of Qi,water and grain transportation,and blood circulation.The theory of Zangfu Bietong in traditional Chinese medicine believes that"the liver is connected to the large intestine"and"the spleen is connected to the small intestine".By discussing the correlation between the liver and spleen,intestinal microbiota,and non-alcoholic fatty liver,the theoretical connotation of liver and spleen coordinated therapy for non-alcoholic fatty liver disease is enriched,and the two major treatment principles of soothing the liver,strengthening the spleen,and promoting spleen circulation and clearing the liver are established,which provide new ideas for the diagnosis and treatment of non-alcoholic fatty liver in traditional Chinese medicine.

关 键 词：非酒精性脂肪性肝病 肠道菌群 肝脾同调 脏腑别通 

分 类 号：R256.43[医药卫生—中医内科学]