基于“肾主生殖”理论探讨中医治疗DOR型不孕症的生物学机制  

Biological mechanism of Chinese medicine in treating DOR type infertility based on the theory of"kidney governing reproduction"

作　　者：赵昱璇 梁启惠 陈雯 韩昀芮 吴海萃[3] ZHAO Yuxuan;LIANG Qihui;CHEN Wen;HAN Yunrui;WU Haicui(School of Chinese Medicine,Shandong University of Chinese Medicine,Jinan,Shandong 250013,China;The First School of Clinical Medicine,Shandong University of Chinese Medicine,Jinan,Shandong 250199,China;Hospital of Shandong University of Chinese Medicine,Jinan,Shandong 250011,China)

机构地区：[1]山东中医药大学中医学院,山东济南250013 [2]山东中医药大学第一临床医学院,山东济南250199 [3]山东中医药大学附属医院,山东济南250011

出　　处：《湖南中医药大学学报》2024年第2期320-326,共7页Journal of Hunan University of Chinese Medicine

基　　金：国家自然科学基金项目(82274573);山东省自然科学基金项目(ZR2021MH255);山东省泰山学者工程项目(tsqn202103182)。

摘　　要：在中医学“肾主生殖”的理论指导下,中医治疗不孕症多以补肾为主。卵巢储备功能下降(diminished ovarian reserve,DOR)是临床导致不孕症的主要病因,DOR型不孕症的发病率逐年增加且发病年龄呈年轻化趋势。中医补肾法在治疗DOR型不孕症方面具有独特优势,其生物学机制主要是调节下丘脑-垂体-卵巢轴神经内分泌功能、抑制卵巢颗粒细胞异常程序性死亡、调节免疫功能、改善卵巢过度氧化应激状态、改善线粒体功能、调节子宫内膜容受性,从而改善卵巢功能,提高生育能力。对近年来中医补肾法治疗DOR型不孕症的生物学机制进行总结,为临床应用“肾主生殖”理论治疗DOR型不孕症提供新思路。Guided by the theory of"kidney governing reproduction",the treatment of infertility in Chinese medicine mainly focuses on tonifying the kidney.Diminished ovarian reserve(DOR)is a common clinical disease leading to infertility.The incidence of DOR type infertility is increasing year by year and the age of onset tends to be younger.The kidney-tonifying method in Chinese medicine has unique advantages in treating DOR type infertility,the biological mechanism of which is mainly related to regulating the neuroendocrine functions of the hypothalamic-pituitary-ovarian axis,inhibiting abnormal programmed death of ovarian granulosa cells,adjusting abnormal immune functions,relieving excessive ovarian oxidative stress,improving the mitochondrial functions,regulating endometrial receptivity to improve ovarian functions,and thus enhancing fertility.This paper has summarized the biological mechanism of the kidney-tonifying method in Chinese medicine for DOR type infertility in recent years,providing new ideas for the clinical application of the"kidney governing reproduction"theory to the treatment of this disease.

关 键 词：肾主生殖 卵巢储备功能下降 不孕症 补肾法 下丘脑-垂体-卵巢轴 生物学机制 

分 类 号：R271.14[医药卫生—中医妇科学]