急性冠状动脉综合征患者行经皮冠状动脉介入术后血清学指标变化及预后分析  

Changes of serological indexes and prognosis of acute coronary syndrome patients after percutaneous coronary intervention

作　　者：李晓宇 张永咏 秦娟 杨忠信[2] LI Xiaoyu;ZHANG Yongyong;QIN Juan;YANG Zhongxin(Department of Cardiovascular Medicine,the First Affiliated Hospital of Henan University,Kaifeng,Henan,475000;Department of Thoracic Surgery,the First Affiliated Hospital of Henan University,Kaifeng,Henan,475000)

机构地区：[1]河南大学第一附属医院心血管内科,河南开封475000 [2]河南大学第一附属医院胸外科,河南开封475000

出　　处：《实用临床医药杂志》2023年第23期60-62,67,共4页Journal of Clinical Medicine in Practice

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20190501)。

摘　　要：目的探讨急性冠状动脉综合征(ACS)患者经皮冠状动脉介入术(PCI)后氨基末端脑钠肽前体(NT-proBNP)、血栓调节蛋白(TM)、C型凝集素样受体2(CLEC-2)、乳糖凝集素-3(Gal-3)的水平变化及其与预后的关系。方法选取ACS患者80例为研究对象。采用门诊复诊或电话随访方式对患者随访6个月,记录患者发生主要不良心血管事件(MACE)的情况。根据MACE发生情况将患者分为MACE组(26例)和对照组(54例),比较2组患者血清学指标变化。结果MACE组患者血清中NT-proBNP、CLEC-2、TM、Gal-3表达水平均较对照组升高,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果发现,NT-proBNP、CLEC-2、TM、Gal-3均为ACS患者PCI后发生MACE的影响因素(P<0.05)。结论NT-proBNP、CLEC-2、TM、Gal-3为ACS患者PCI后发生MACE的影响因素,对于患者是否发生MACE具有良好预测作用。Objective To investigate the levels of N-terminal probrain natriuretic peptide(NT-proBNP),thrombolomodulin(TM),C-type lectin-like receptor 2(CLEC-2),galectin-3(Gal-3)and their relationships with prognosis in patients with acute coronary syndrome(ACS)after percutaneous coronary intervention(PCI).Methods A total of 80 patients with ACS were selected as study objects.The patients were followed up for 6 months by outpatient visit or telephone follow-up,and the occurrence of major adverse cardiovascular events(MACE)was recorded in the patients.According to the occurrence of MACE,patients were divided into MACE group(26 cases)and control group(54 cases).The changes of serological indexes were compared between the two groups.Results The expression levels of NT-proBNP,CLEC-2,TM and Gal-3 in serum of patients in the MACE group were significantly higher than those of control group(P<0.05).Multivariate Logistic regression analysis showed that NT-proBNP,CLEC-2,TM,and Gal-3 were all influential factors for the occurrence of MACE after PCI in ACS patients(P<0.05).Conclusion NT-proBNP,CLEC-2,TM and Gal-3 are influencing factors for MACE in patients with ACS after PCI,and have a good predictive role in evaluating the occurrence of MACE.

关 键 词：急性冠状动脉综合征 经皮冠状动脉介入术 主要不良心血管事件 预后 多因素LOGISTIC回归分析 预测 

分 类 号：R446[医药卫生—诊断学] R605[医药卫生—临床医学] R543.3