氯喹类药物对心肌细胞离子通道的影响  

Effects of chloroquine drugs on ionicchannels of myocardial cells

作　　者：刘欣藜 梁好 许正新[1,2,3,4] LIU Xinli;LIANG Hao;XU Zhengxin(Medical College of Yangzhou University,Yangzhou,Jiangsu,225000;Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses,Yangzhou,Jiangsu,225001;Key Laboratory of Integrative Medicine Prevention and Treatment for Senile Diseases in Jiangsu Province,Yangzhou,Jiangsu,225001;Jiangsu Key Laboratory of Noncoding RNA Basic and Clinical Transformation,Yangzhou,Jiangsu,225009)

机构地区：[1]扬州大学医学院,江苏扬州225000 [2]江苏省重点动物传染病和人畜共患病预防控制共创中心,江苏扬州225001 [3]江苏省中西医结合老年病防治重点实验室,江苏扬州225001 [4]江苏省非编码RNA基础与临床转化重点实验室,江苏扬州225009

出　　处：《实用临床医药杂志》2023年第23期135-138,148,共5页Journal of Clinical Medicine in Practice

基　　金：国家自然科学基金项目(82174129);扬州大学大学生科研创新计划项目(X20210733)。

摘　　要：作为传统抗疟药,氯喹类药物在疟疾控制方面发挥了极其重要的作用。近年来,随着临床应用深度和广度的扩展,氯喹类药物在其他方面的应用价值不断被挖掘和开发出来,例如抗炎、免疫抑制、抗肠虫等,而在新型冠状病毒感染疫情暴发时,氯喹同类物羟氯喹也被迅速纳入多国的治疗方案中。然而众多文献证明,氯喹类药物可引起心律失常等心脏不良反应(延长QT间期,增加扭转性室性心动过速发生风险),故临床使用时应严格掌握适应证和禁忌证。为了进一步规范氯喹类药物的临床应用,更好地为临床服务,本文从离子通道的角度对该类药物心脏不良反应发生的电生理基础和临床特征进行综述。Chloroquine has played a pivotal role in the treatment of malaria.Recently,with the development of clinical application,they are increasingly recognized for their effectiveness in other aspects,such as anti-inflammation,immunosuppression,anti-amoebic effects and so on.In the outbreak of the new coronavirus infection,chloroquine and its derivative hydroxychloroquine swiftly included in the treatment of infected patients in many countries.However,several studies have shown these drugs have some detrimental influence,especially in cardiac arrhythmia(prolonged the QT interval and increased risk of torsional ventricular tachycardia).Thus,we should pay attention to both their beneficial effects and potential adverse manifestation.In order to regulate the use of drugs and guide the clinic,this paper reviewed the electrophysiological basis and clinical characteristics of cardiac adverse reactions of these drugs from the perspective of ion channels.

关 键 词：氯喹 心脏毒性作用 心律失常 离子通道 

分 类 号：R453[医药卫生—治疗学] R969[医药卫生—临床医学] R541