血Fib、TNI、TnT及Lp-PLA2与急性心肌梗死预后的相关性分析  

Correlation analysis of blood fibrinogen,troponin I,troponin T and lipoprotein associated phospholipase A2 with the prognosis of acute myocardial infarction

作　　者：邓莹 沈丽娟[2] 储云鹏 DENG Ying;SHEN Lijuan;CHU Yunpeng(Department of Clinical Laboratory,Affiliated Hospital of Jiangnan University,Jiangsu,Wuxi 214122,China;不详)

机构地区：[1]江南大学附属医院检验科,江苏省无锡市214122 [2]江苏省无锡市中医医院心血管科 [3]江苏省无锡市中医医院检验科

出　　处：《河北医药》2024年第1期48-51,共4页Hebei Medical Journal

基　　金：江苏省自然科学基金面上项目(编号:BK20201141);无锡市中医医院院内课题(编号:ZYYYB21017)。

摘　　要：目的 探讨血纤维蛋白原(Fib)、肌钙蛋白I(TNI)、肌钙蛋白T(TnT)及脂蛋白相关磷脂酶A2(Lp-PLA2)与急性心肌梗死(AMI)预后的相关性。方法 选取2020至2021年诊治的AMI患者122例作为研究组,入院后第3个月按照发生不良心血管事件(MACE)将AMI患者分为预后不良组(发生MACE)39例和预后良好组(未发生MACE)83例,并选取同期体检的健康志愿者40例作为对照组。比较研究组与对照组、预后不良组和预后良好组的血Fib、TNI、TnT及Lp-PLA2水平,并分析血Fib、TNI、TnT及Lp-PLA2对AMI患者预后不良的预测价值。结果 研究组血Fib、TNI、TnT、Lp-PLA2明显高于对照组(P<0.05)。预后不良组血Fib、TNI、TnT、Lp-PLA2明显高于预后良好组(P<0.05)。受试者工作特征(ROC)曲线分析显示,Fib、TNI、TnT、Lp-PLA2、四者联合预测AMI患者预后不良的曲线下面积(AUC)分别为0.826、0.816、0.878,0.947、0.947,在最佳临界值对应的敏感度、特异度分别为:Fib为56.4%、100%,TNI为51.3%、100%,TnT为51.3%、100%,Lp-PLA2为76.9%、84.3%,四者联合为82.1%、100%。结论 AMI患者血Fib、TNI、TnT及Lp-PLA2水平呈高表达,且预后不良血Fib、TNI、TnT及Lp-PLA2水平越高;血Fib、TNI、TnT及Lp-PLA2四者联合对AMI患者预后不良具有较高的预测价值。Objective To analyze the correlation of fibrinogen(Fib),troponin I(TNI),troponin T(TnT) and lipoprotein associated phospholipase A2(Lp-PLA2) with the prognosis of acute myocardial infarction(AMI).Methods A total of 122 AMI patients who were diagnosed and treated from 2020 to 2021 were selected as the study group.According to the presence or absence of adverse cardiovascular events(MACEs) at 3 months after admission,AMI patients were divided into poor prognosis group(n=39) and good prognosis group(n=83).During the same period,40 healthy volunteers were selected as the control group.Blood FIB,TNI,TnT and Lp-PLA2 levels between the study group and the control group,and between the poor prognosis group and the good prognosis group were compared.Their predictive value for the poor prognosis of AMI patients was explored.Results The blood FIB,TNI,TnT and Lp-PLA2 levels in the study group were significantly higher than those in the control group(P<0.05),which were significantly higher in the poor prognosis group than those in the good prognosis group(P<0.05).The receiver operating characteristic(ROC) curves showed that the area under the curve(AUC) of FIB,TNI,TnT,Lp-PLA2 and their combination detection to predict the poor prognosis of AMI patients was 0.826(sensitivity=56.4% and specificity=100%),0.816(sensitivity=51.3% and specificity=100%),0.878(sensitivity=51.3% and specificity=100%),0.947(sensitivity=76.9% and specificity=84.3%) and 0.947(sensitivity=82.1% and specificity=100%),respectively.Conclusion Blood FIB,TNI,TnT and Lp-PLA2 are highly expressed in AMI patients,which are significantly higher in those with a poor prognosis.Their combination detection offers a high predictive value for the poor prognosis of AMI patients.

关 键 词：血纤维蛋白原 肌钙蛋白I 肌钙蛋白T 脂蛋白相关磷脂酶A2 急性心肌梗死 预后 

分 类 号：R542.22[医药卫生—心血管疾病]