糖尿病周围神经病变患者血清Hcy、NSE水平变化及临床意义  

Changes in serum HCY and NSE levels in patients with diabetic peripheral neuropathy and their clinical significances

作　　者：张钢[1] 杨志森 ZHANG Gang;YANG Zhisen(Handan First Hospital,Hebei,Handan 056500,China)

机构地区：[1]河北省邯郸市第一医院内分泌一科,056500 [2]河北省邯郸市第一医院综合外科,056500

出　　处：《河北医药》2024年第1期64-66,71,共4页Hebei Medical Journal

摘　　要：目的 分析糠尿病周围神经病变(DPN)患者血清同型半胱氨酸(Hcy)、神经元特异性(NSE)水平变化及临床意义。方法 选取内分泌科2020年2月至2022年2月就诊的60例糖尿病(DM)患者,根据是否发生DPN分组,将31例单纯DM患者作为试验1组,将29例DPN患者作为试验2组,选取2020年2月至2022年2月体检中心30例健康体检者作为对比组,对比3组血糖、血清Hcy、NSE、神经传导功能,Spearman相关性分析血清Hcy、NSE与血糖、神经传导功能的相关性。结果 试验2组FPG、2hPG、HbA1c均高于试验1组,试验1组均高于对比组(P<0.05)。试验2组血清Hcy、NSE均高于试验1组,试验1组血清Hcy、NSE均高于对比组(P<0.05)。试验2组MN感觉传导速度、运动传导速度、CPN感觉传导速度、运动传导速度均低于试验1组,试验1组均低于对比组(P<0.05);试验2组MN F波潜伏期、CPN H反射潜伏期均高于试验1组,试验1组均高于对比组(P<0.05)。Hcy、NSE与FPG、2hPG、HbA1c、MN感觉及运动传导速度、CPN感觉及运动传导速度均呈正相关性(r值均>1),Hcy、NSE与MN F波及CPN H反射潜伏期呈负相关性(r值均<1)。(P<0.05)。结论 DPN患者机体血清Hcy、NSE较高,血清Hcy、NSE浓度越高,神经传导功能受损越严重,可通过动态监测血清Hcy、NSE变化,评估DPN患者疾病进展程度。Objective To analyze the changes in serum homocysteine(Hcy) and neuron-specific enolase(NSE) levels in patients with diabetic peripheral neuropathy(DPN) and their clinical significances.Methods A total of 60 patients with diabetes mellitus(DM) who visited the Department of Endocrinology in our hospital from February 2020 to February 2022 were selected and grouped according to the presence of DPN or not.They were divided into experimental group 1(n=31,DM patients) and experimental group 2(n=29,DPN patients).During the same period,a total of 30 healthy volunteers receiving physical examination were recruited in the control group.Blood glucose,serum Hcy,NSE,and nerve conduction function were detected and compared among the three groups.Spearman correlation analysis was performed to analyze the correlation of serum Hcy and NSE with blood glucose and nerve conduction function.Results The fasting plasma glucose(FPG),2-hour plasma glucose(2hPG) and hemoglobin A1C(HbA1c) of the experimental group 2 were significantly higher than those of the experimental group 1,which,in the experimental group 1 were significantly higher than those of the control group(P<0.05).Serum Hcy and NSE in experimental group 2 were significantly higher than those of experimental group 1,which,in experimental group 1 were significantly higher than those of control group(P<0.05).The sensory conduction velocity and motor conduction velocity of the motor nerve(MN),and the sensory conduction velocity and motor conduction velocity of common peroneal nerve(CPN) in the experimental group 2 were significantly lower than those of the experimental group 1,which,in the experimental group 1 were significantly lower than those of the control group(P<0.05).The F-wave latency of the MN and H-reflex latency of the CPN in the experimental group 2 were significantly higher than those of the experimental group 1,which,in the experimental group 1 were significantly lower than those of the control group(P<0.05).Hcy and NSE were positively correlated with the FPG,2hPG,

关 键 词：糖尿病周围神经病变 同型半胱氨酸 神经元特异性烯醇化酶 神经传导功能 

分 类 号：R587.2[医药卫生—内分泌]