阿莫西林克拉维酸钾及替硝唑综合疗法对胃炎患儿的疗效及对hs-CRP、TNF-α、IL-10水平的影响  

Therapeutic efficacy of amoxicillin/clavulanate potassium combined with tinidazole on children with gastritis and the regulatory effect on hs-CRP,TNF-α and IL-10 levels

作　　者：胡淑娟 HU Shujuan(The Eighth Hospital of Wuhan,Hubei,Wuhan 430000,China)

机构地区：[1]湖北省武汉市第八医院,430000

出　　处：《河北医药》2024年第1期72-74,79,共4页Hebei Medical Journal

摘　　要：目的 研究阿莫西林克拉维酸钾及替硝唑综合疗法对胃炎患儿的疗效及对超敏C-反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白介素-10(IL-10)水平的影响。方法 选择2019年7月至2021年7月收治的84例胃炎患儿,随机双盲对照法将其分为二药联合组及单药治疗组,每组42例。单药治疗组予以阿莫西林克拉维酸钾治疗,二药联合组则于单药治疗组的基础上增用替硝唑治疗。比较2组临床疗效,血清炎症指标及免疫功能指标水平,不良反应发生情况。结果 二药联合组治疗总有效率高于单药治疗组(P<0.05)。治疗前2组hs-CRP、TNF-α以及IL-10水平差异无统计学意义(P>0.05);治疗后,二药联合组血清hs-CRP、TNF-α水平均低于单药治疗组,而血清IL-10水平,高于单药治疗组(P<0.05)。治疗前,2组CD3^(+)、CD4^(+)以及CD8^(+)水平差异无统计学意义(P>0.05);治疗后,二药联合组CD3^(+)、CD4^(+)以及CD8^(+)水平均高于单药治疗组(均P<0.05)。二药联合组不良反应总发生率低于单药治疗组(P<0.05)。结论 阿莫西林克拉维酸钾及替硝唑综合疗法可提高胃炎患儿疗效,尤其是在减轻炎性反应及提高免疫功能方面优势明显,且有效降低不良反应发生风险。Objective To explore the therapeutic efficacy of amoxicillin/clavulanate potassium combined with tinidazole on children with gastritis and the regulatory effect on hypersensitive C-reactive protein(hs-CRP),tumor necrosis factor alpha(TNF-α) and interleukin 10(IL-10) levels.Methods A total of 84 children with gastritis admitted from July 2019 to July 2021 were selected.They were randomly divided into two-drug combination group and monotherapy group by double-blind control method,with 42 cases in each group.Patients in the monotherapy group were treated with amoxicillin/clavulanate potassium,and those in the two-drug combination group were treated with amoxicillin/clavulanate potassium combined with tinidazole.The clinical efficacy,serum inflammatory indexes,immune function indexes,and the incidence of adverse events were compared between the two groups.Results The total effective rate of the two-drug combination group was significantly higher than that of the monotherapy group(P<0.05).Before treatment,there were no significant differences in hs-CRP,TNF-α and IL-10 levels between the two groups(P>0.05).After treatment,serum hS-CRP and TNF-α levels in the two-drug combination group were significantly lower than those of monotherapy group,but serum IL-10 was significantly higher(P<0.05).Before treatment,there were no significant differences in CD3^(+),CD4^(+) and CD8^(+) levels between the two groups(P>0.05),which,after treatment,were significantly higher in the two-drug combination group than those of monotherapy group(P<0.05).The total incidence of adverse events in the two-drug combination group was significantly lower than that of the monotherapy group(P<0.05).Conclusion Amoxicillin/clavulanate potassium combined with tinidazole can improve the efficacy of children with gastritis,especially in reducing inflammation and improving immune function.It effectively reduces the risk of adverse events.

关 键 词：小儿胃炎 阿莫西林克拉维酸钾 替硝唑 炎性反应 免疫功能 

分 类 号：R725.7[医药卫生—儿科]