慢性阻塞性肺疾病患者血浆溶血磷脂酸和可溶性ST2的表达水平及其临床意义  

The expression and clinical significance of lysophosphatidic acid and soluble ST2 in plasma of patients with chronic obstructive pulmonary disease

作　　者：洪静雪 黄钟[2] 张妤 卢献灵[1] HONG Jingxue;HUANG Zhong;ZHANG Yu;LU Xianling(Department of Respiratory Medicine,The First Affiliated Hospital of Shihezi University School of Medicine,Shihezi 832000,Xinjiang,China;Department of Emergency,The First Affiliated Hospital of Shihezi University School of Medicine,Shihezi 832000,Xinjiang,China)

机构地区：[1]石河子大学医学院第一附属医院呼吸内一科,新疆石河子832000 [2]石河子大学医学院第一附属医院急诊内科,新疆石河子832000

出　　处：《西部医学》2024年第1期57-62,共6页Medical Journal of West China

基　　金：2022年度兵团指导性科技计划项目(2022ZD039)。

摘　　要：目的研究慢性阻塞性肺疾病(COPD)患者血浆中溶血磷脂酸(LPA)、可溶性ST2(sST2)的表达水平及其临床意义。方法选取本院2021年10月-2022年6月收治的42例急性加重COPD患者作为急性加重期组,接受治疗后,将其纳入稳定期组,并将40例健康受试者纳入对照组。收集各组的基本资料及外周血,检测COPD患者及对照组的肺功能,并通过酶联免疫吸附法检测血浆中LPA和sST2水平。结果COPD急性加重期的LPA、sST2水平均高于稳定期组,差异有统计学意义(均P<0.05);急性加重期和稳定期的LPA、sST2水平均高于对照组,差异有统计学意义(均P<0.05);在急性加重期和稳定期,LPA水平均与sST2水平呈正相关;急性加重期LPA、sST2水平与白细胞计数、中性粒细胞百分比、红细胞分布宽度、中性粒细胞与淋巴细胞比率、白蛋白呈正相关,LPA水平与单核细胞与高密度脂蛋白比率呈正相关,sST2水平与嗜酸性粒细胞计数呈正相关;稳定期LPA、sST2水平与第1秒用力呼气容积占预计值百分比(FEV1%pred)、第1秒用力呼气容积/用力肺活量比值(FEV1/FVC)呈负相关,与白细胞计数、中性粒细胞百分比、红细胞分布宽度、中性粒细胞/淋巴细胞比率呈正相关,LPA水平与血小板/淋巴细胞比率呈正相关,sST2水平与嗜酸性粒细胞计数、白蛋白呈正相关。结论LPA和sST2的水平在COPD患者外周血中升高,两者水平呈正相关,并且与肺功能、临床指标相关,提示LPA和sST2可能共同参与慢阻肺的发生发展。Objective To investigate the expression levels of lysophosphatidic acid(LPA) and soluble ST2(sST2) in plasma of patients who had COPD and their clinical significance.Methods Forty-two patients with acute exacerbation COPD(AECOPD) who were hospitalized in the First Affiliated Hospital of Shihezi University School of Medicine from October 2021 to June 2022 were selected as the AECOPD group,and recruited in the stable COPD group when they received treatment and entered the stable period.In the same period,forty healthy individuals were recruited in the control group.The general information and peripheral blood were collected from each group.the pulmonary function test was tested in the stable and control group,and the LPA and sST2 levels were measured by enzyme-linked immunosorbent assay.Results The levels of LPA and sST2 in the AECOPD group were higher than those in the stable group,with statistical significance(both P<0.05),and the levels of LPA and sST2 in the AECOPD group and stable group were higher than those in the control group,with statistical significance(all P<0.05).The levels of LPA in AECOPD group and stable group were both positively correlated with the levels of sST2.The levels of LPA and sST2 in AECOPD group were positively correlated with white blood cell count,neutrophil percentage,red blood cell distribution width,neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio,and albumin,and the levels of LPA in AECOPD group was positively correlated with monocyte-to-high density lipoprotein ratio,the levels of sST2 in AECOPD group was positively correlated with eosinophil count.The levels of LPA and sST2 in COPD group were negatively correlated with FEV1%pred,FEV1/FVC,and were positively correlated with white blood cell count,neutrophil percentage,red blood cell distribution width,and neutrophil-to-lymphocyte ratio.The levels of LPA were positively correlated with platelet-to-lymphocyte ratio,and the levels of sST2 were positively correlated with eosinophil count and albumin.Conclusion The levels of

关 键 词：慢性阻塞性肺疾病 溶血磷脂酸 可溶性ST2 慢性炎症 

分 类 号：R563[医药卫生—呼吸系统]