结缔组织病相关间质性肺疾病患者生活质量的影响因素分析  

Analysis on the influencing factors of quality of life in patients with connective tissue disease-associated interstitial lung disease

作　　者：刘乾泰 马艳[2] 刘乃鹏 李甜甜 孙梦雯 胡晓文 Liu Qiantai*;Ma Yan;Liu Naipeng;Li Tiantian;Sun Mengwen;Hu Xiaowen(Graduate School of Bengbu Medical College,Bengbu 233030,China;不详)

机构地区：[1]蚌埠医学院研究生院,蚌埠233030 [2]中国科学技术大学附属第一医院(安徽省立医院)风湿免疫科 [3]中国科学技术大学附属第一医院(安徽省立医院)病案统计室 [4]中国科学技术大学附属第一医院(安徽省立医院)老年医学科 [5]中国科学技术大学附属第一医院(安徽省立医院)呼吸与危重症医学科

出　　处：《中国临床保健杂志》2023年第6期803-809,共7页Chinese Journal of Clinical Healthcare

摘　　要：目的 回顾性分析结缔组织病相关间质性肺疾病(CTD-ILD)患者生活质量,探索影响患者生活质量的相关因素。方法 选取2022年11月至2023年8月中国科学技术大学附属第一医院(安徽省立医院)风湿免疫科的部分CTD-ILD住院患者(CTD-ILD组)及同时期体检健康者(健康对照组),对2组人群进行问卷调查,并分析CTD-ILD患者相关资料。通过多元线性回归分析CTD-ILD患者生活质量的影响因素。结果 最终共纳入86例CTD-ILD患者及57例健康对照者,2组人群基线资料差异无统计学意义(P>0.05)。CTD-ILD组健康状况调查问卷(SF-36)中生理健康总分(PCS)、心理健康总分(MCS)得分及世界卫生组织生活质量测定量表简表(WHOQOL-BREF)各领域得分与健康对照组相比均较低,差异有统计学意义(P<0.05)。单因素分析显示不同性别、年龄、居住地、文化程度、医保类型、病程、近1年住院次数以及伴或不伴疼痛的CTD-ILD患者,生活质量差异有统计学意义(P<0.05)。Spearman相关性分析显示,SF-36中PCS、MCS得分及WHOQOL-BREF各领域得分与改良版医学研究委员会呼吸困难问卷(mMRC)分级均呈负相关(r=-0.466~-0.271,P<0.05);SF-36中PCS得分及WHOQOL-BREF各领域得分与查尔森共病指数(CCI)均呈负相关(r=-0.422~-0.273,P<0.05);SF-36中PCS得分及WHOQOL-BREF中生理领域、心理领域、环境领域得分与Barthel指数均呈正相关(r=0.261~0.445,P<0.05)。多元线性回归结果显示,性别、年龄、居住地、文化程度、疼痛、近1年住院次数、mMRC分级、CCI、Barthel指数为CTD-ILD患者生活质量的独立影响因素(P<0.05)。结论 CTD-ILD患者生活质量较低;女性、年龄≥45岁、居住于农村、文化程度较低、呼吸困难程度较重、疼痛、共病情况较严重、日常生活能力较差以及近1年住院次数较多为CTD-ILD患者生活质量下降的重要影响因素。Objective To retrospectively analyze the quality of life in patients with connective tissue disease-associated interstitial lung disease(CTD-ILD)and explore the influencing factors of their quality of life.Methods A questionnaire survey was conducted on a group of inpatients with CTD-ILD from department of rheumatology and immunology in the First Affiliated Hospital of University of Science and Technology of China from November,2022 to August,2023(classified as the CTD-ILD group),along with a healthy control group consisting of some healthy individuals residing during the same period.The relevant data of CTD-ILD patients were analyzed and the factors influencing their quality of life were examined through multiple linear regression analysis.Results A total of 86 CTD-ILD patients and 57 healthy controls were ultimately enrolled,and no significant differences were observed in the baseline characteristics between the two groups(P>0.05).The physical component summary(PCS)and mental component summary(MCS)scores in The MOS 36-Item Short-Form Health Survey(SF-36),as well as the scores of each domain of World Health Organization Quality of Life-Brief Version(WHOQOL-BREF),were lower in the CTD-ILD group compared with those in the healthy control group,and the difference was statistically significant(P<0.05).Univariate analysis showed significant differences in the quality of life in CTD-ILD patients among gender,age,place of residence,education attainment,type of medical insurance,duration of illness,number of hospitalizations within the previous year,and presence or absence of pain(P<0.05).Spearman correlation analysis showed that PCS,MCS scores,and scores in each domain of WHOQOL-BREF were negatively correlated with the modified Medical Research Council(mMRC)grades(r=-0.466--0.271,P<0.05).PCS scores and scores in each domain of WHOQOL-BREF exhibited a negative correlation with Charlson comorbidity index(CCI)(r=-0.422--0.273,P<0.05).PCS scores and scores in the physical,psychological,and environment domains of WHOQOL-BRE

关 键 词：肺疾病 间质性 结缔组织疾病 生活质量 危险因素 

分 类 号：R563[医药卫生—呼吸系统]