巨噬细胞极化在高血压病中的作用及中医药干预研究进展  

Role of macrophage polarization in hypertension and traditional Chinese medicine intervention: a review

作　　者：杨振宇 李纪新 顾晨浩 李丙泉 李晨[1] 郭丹丹[1,3] YANG Zhen-yu;LI Ji-xin;CU Chen-hao;LI Bing-quan;LI Chen;GUO Dan-dan(Heilongjiang University of Chinese Medicine,Harbin 150040,China;Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China;the Second Affiliated Hospital of Heilongjiang University of TCM,Harbin 150001,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]中国中医科学院西苑医院,北京100091 [3]黑龙江中医药大学附属第二医院,黑龙江哈尔滨150001

出　　处：《中国中药杂志》2024年第1期15-25,共11页China Journal of Chinese Materia Medica

基　　金：黑龙江省中医药科研项目(ZHY2020-148);黑龙江省中医药科研项目(ZHY2023-174);黑龙江省哈尔滨市科技局应用技术研究与开发项目(2017RAQXJ208)。

摘　　要：高血压是一种慢性低度炎症状态,是继发心力衰竭、冠心病以及动脉粥样硬化的关键危险因素。循环系统的巨噬细胞是参与人体免疫及炎症反应的主要细胞群,根据微环境的不同,可极化为促炎的M1表型及抑炎的M2表型。当血压升高时,表现为M1释放炎性细胞因子和趋化因子,发挥免疫反应;过度的免疫反应必然会导致组织损伤,故M2释放抗炎因子以促进伤口的愈合及组织的修复。M1与M2的动态平衡与中医阴阳理论环环相扣,阴阳失调则机体呈现病理状态,表现为血压节律的改变。现有研究证实,中药可通过调控巨噬细胞极化,对高血压病产生积极的疗效。故作者从巨噬细胞极化角度切入,整合所有中医药调控巨噬细胞极化的研究,对其干预高血压病的机制进行综述,以期为临床治疗提供证据,为科研设计提供思路。Hypertension is known to be a chronic inflammatory state and a key risk factor for heart failure, coronary heart disease, and atherosclerosis. Macrophages in the circulatory system are the main cell group that constitutes the immune system and participates in the inflammatory response. Depending on the local microenvironment, macrophages can be polarized into pro-inflammatory(M1) and anti-inflammatory(M2) phenotypes. When blood pressure is elevated, M1 macrophages can release pro-inflammatory cytokines and chemokines to generate an immune response. However, an excessive immune response can lead to tissue damage, and M2 macrophages release anti-inflammatory cytokines to promote the repair of wounds and tissue damage. It is clear that the dynamic balance between M1 and M2 macrophages resembles the traditional Chinese medicine(TCM) theory of Yin and Yang. That is, when Yin and Yang are imbalanced, the human body will exhibit pathological states, e.g., altered blood pressure rhythms. Studies have confirmed that TCM can produce positive therapeutic effects on hypertension by regulating macrophage polarization. Therefore, this study reviews the studies about the TCM regulation of macrophage polarization and summarized the mechanisms of TCM intervention in hypertension, with the aim of providing evidence for clinical treatment and ideas for scientific research design.

关 键 词：高血压病 炎症 巨噬细胞极化 中医药 作用靶点 阴阳理论 

分 类 号：R259[医药卫生—中西医结合]