新型BC佐剂系统的研究进展  

Progress in research on novel BC adjuvant system

作　　者：江秋虹 陶立峰(综述) 王国治[2] 赵爱华(审校)[2] JIANG Qiuhong;TAO Lifeng;WANG Guozhi;ZHAO Aihua(Anhui Zhifei Longcom Biopharmaceutical Co.,Ltd,Hefei 230088,Anhui Province,China;不详)

机构地区：[1]安徽智飞龙科马生物制药有限公司,安徽合肥230088 [2]中国食品药品检定研究院,北京102629

出　　处：《中国生物制品学杂志》2024年第1期99-105,共7页Chinese Journal of Biologicals

基　　金：国家科技重大专项(2018ZX10731301)。

摘　　要：国外已有应用新型佐剂的疫苗上市,国内除铝佐剂广泛应用于疫苗研发生产外,鲜有其他新型佐剂成功上市。本文针对已应用于疫苗临床研究阶段具有自主知识产权的新型BC佐剂系统的来源、发展历史以及生物学活性和免疫机制的研究进展、安全性评价等作一简要综述,为新型疫苗研发中选择该佐剂提供理论支持。Vaccines with novel adjuvants have been listed abroad,while in China,except for aluminum adjuvants widely used in vaccine research and production,few other novel adjuvants have been successfully listed.This paper briefly summarized the source,development history,research progress on biological activity and immune mechanism as well as safety evaluation of the novel BC adjuvant system with independent intellectual property right which has been applied to the vaccine in clinical research stage,so as to provide theoretical support for selection of the adjuvant in the development of novel vaccine.

关 键 词：新型佐剂 BC佐剂系统 BCG-CPG-DNA 新型疫苗 

分 类 号：Q-1[生物学]