长期小剂量阿奇霉素治疗支气管扩张症的效果  

Effect of long-term low dose azithromycin on bronchiectasis

作　　者：耿洁 顾明芳[1] GENG Jie;GU Mingfang(Department of Respiratory and Critical Care Medicine,Suzhou Xiangcheng People's Hospital,Suzhou,Jiangsu 215131,China)

机构地区：[1]苏州市相城人民医院呼吸与危重症医学科,江苏苏州215131

出　　处：《医药前沿》2024年第2期17-19,共3页Journal of Frontiers of Medicine

摘　　要：目的:探究支气管扩张症应用小剂量阿奇霉素进行长期持续治疗的效果。方法:选取2021年1月—2023年1月苏州市相城人民医院收治的支气管扩张症患者128例,住院前核酸筛查均为阴性,依随机数字表法分为对照组和观察组,每组64例。对照组行常规氨溴索口服治疗,观察组行小剂量阿奇霉素长期治疗,比较两组临床症状、免疫功能及肺功能。结果:治疗后,两组呼吸困难评分均低于治疗前,日痰量少于治疗前,观察组呼吸困难评分低于对照组,日痰量少于对照组,差异有统计学意义(P<0.05)。治疗后,两组CD4^(+)T细胞比例及CD4^(+)/CD8^(+)均高于治疗前,CD8^(+)T细胞比例均低于治疗前,观察组CD4^(+)T细胞比例及CD4^(+)/CD8^(+)高于对照组,CD8^(+)T细胞比例低于对照组,差异有统计学意义(P<0.05)。治疗后,两组第1秒用力呼气量(FEV_(1))、用力肺活量(FVC)、FEV_(1)/FVC水平均大于治疗前,观察组FEV_(1)、FVC、FEV_(1)/FVC水平大于对照组,差异有统计学意义(P<0.05)。结论:支气管扩张症患者长期应用小剂量阿奇霉素治疗的效果较好,可有效改善患者临床症状,提高其免疫功能及肺功能。Objective Analysis of the long-term treatment effect of low-dose azithromycin on patients with bronchiectasis.Methods 128 patients with bronchiectasis admitted to Suzhou Xiangcheng People's Hospital from January 2021 to January 2023 were selected as the research subjects.Those who had negative nucleic acid screening before hospitalization were randomly divided into a control group and an observation group,with 64 cases in each group,using a random number table method.The control group received routine oral treatment with ambroxol,while the observation group received long-term treatment with low-dose azithromycin.Clinical symptom indicators,immune function,and lung function levels were compared between the two groups.Results After treatment,the dyspnea scores of the two groups were lower than those before treatment,and the daily sputum volume was less than that before treatment.The dyspnea score of the observation group was lower than another group,and the daily sputum volume was less than another group(P<0.05).After treatment,the proportion of CD4^(+)T cells and CD4^(+)/CD8^(+)in the two groups were higher than those before treatment,and the proportion of CD8^(+)T cells was lower than that before treatment.The proportion of CD4^(+)T cells and CD4^(+)/CD8^(+)in the observation group were higher than another group,and the proportion of CD8^(+)T cells was lower than another group(P<0.05).After treatment,the levels of forced expiratory volume in first second(FEV_(1)),forced vital capacity(FVC)and FEV_(1)/FVC in the observation group were higher than another group(P<0.05).Conclusions The long-term treatment of bronchiectasis with low-dose azithromycin has a significant effect,which can effectively enhance their immune and lung functions.

关 键 词：支气管扩张症 阿奇霉素 肺功能 免疫功能 

分 类 号：R563.1[医药卫生—呼吸系统]