基质金属蛋白酶-7在新生儿胆道闭锁诊断和预后评价中的研究进展  

Research advances of matrix metalloproteinase-7 in the diagnosis and prognosis of neonatal biliary atresia

作　　者：张子涵 姚翼 张文红 迟云倩 郝薇 Zhang Zihan;Yao Yi;Zhang Wenhong;Chi Yunqian;Hao Wei(Department of Neonatology,Affiliated Shandong Provincial Hospital,Shandong First Medical University,Jinan 250021,China;College of Basic Medicine,Guangxi Medical University,Nanning 530021,China)

机构地区：[1]山东第一医科大学附属省立医院新生儿科,济南250021 [2]广西医科大学基础医学院,南宁530021

出　　处：《中华小儿外科杂志》2024年第1期77-81,共5页Chinese Journal of Pediatric Surgery

基　　金：山东省自然科学基金(ZR2020MH073);济南市临床医学科技创新计划(202328068)。

摘　　要：胆道闭锁(biliary atresia,BA)是以肝内、外胆管进行性炎症和纤维化为特征的严重肝胆疾病,早期诊断难度大,易延误患儿Kasai手术时机,部分患儿术后仍需接受肝移植,进展严重的患儿甚至死亡。基质金属蛋白酶-7(matrix metalloproteinase-7,MMP-7)是基质金属蛋白酶家族之一,能够降解细胞外基质和其他基质,与BA联系紧密。本文主要介绍目前MMP-7在BA诊断和预后评价中的研究进展,并对相关研究结果予以概述和探讨。As a rare disease of infancy,biliary atresia(BA)is characterized by progressive inflammation and fibrination of intra/extra-hepatic bile ducts.The difficulty of early diagnosis of this disease results in an advanced age at Kasai surgery and a significantly higher rate of postoperative mortality and liver transplantation.Matrix metalloproteinase-7(MMP-7)is a matrix metalloproteinase capable of degrading extracellular matrix and other matrices.It is correlated closely with BA.In basic experiments,serum level of MMP-7 in BA children was significantly higher than that of non-BA subjects.This review focused upon the latest researches of MMP-7 in the diagnosis and prognosis of BA.

关 键 词：胆道闭锁 基质金属蛋白酶 诊断 评价 

分 类 号：R722.1[医药卫生—儿科]