献血者使用HIV抗病毒治疗药物对血液安全的影响  

HIV antiretroviral therapy among blood donors:the impact on blood safety

作　　者：王立林[1] 赵方[2] 杨峥嵘[3] 朱蕊 刘宜仲 邬林枫[1] 李彤[1] 陈婷婷 曾劲峰[1] WANG Lilin;ZHAO Fang;YANG Zhengrong;ZHU Rui;LIU Yizhong;WU Linfeng;LI Tong;CHEN Tingting;ZENG Jinfeng(Shenzhen Blood Center,Shenzhen 518035,China;Shenzhen Third People′s Hospital;Shenzhen Center for Disease Control and Prevention;Shenzhen Bao′an District Central Blood Bank.)

机构地区：[1]深圳市血液中心,广东深圳518035 [2]深圳市第三人民医院 [3]深圳市疾病预防控制中心 [4]深圳市宝安区中心血站

出　　处：《中国输血杂志》2024年第2期138-144,共7页Chinese Journal of Blood Transfusion

基　　金：2020年度广东省医学基金项目(A2020259);深圳市医学重点学科建设经费(SZXK070);深圳市医疗卫生三名工程项目(SZSM2023028);深圳市血液中心科研课题(SZBC202202)。

摘　　要：目的分析深圳市无偿献血者中使用抗病毒治疗(ART)药物对血液安全的潜在风险。方法应用液相色谱-质谱联用技术(HPLC-MS/MS),检测定期献血者(阴性对照组n=86)、抗-HIV阳性检出者(实验组n=98,检出于2019—2023年约44万献血者)血浆中ART药物,探明阴性对照组ART药物血浆基线浓度,分析使用ART药物对血液安全的影响。结果86例阴性对照组血浆标本未检测到基线浓度的ART药物;98例实验组1∶2人份混合血浆标本中,经拆分确证检出4例ART药物标本,ART药物检出率为4.08%。其中,3例检出ART药物替诺福韦、拉米夫定、依非韦伦,1例检出拉米夫定、洛匹那韦、利托那韦、齐多夫定。结论深圳地区抗-HIV阳性检出者中存在使用ART药物情况,需要进一步探究此类人群献血动机,识别高危人群,保障血液安全。Objective To explore the the potential risks of antiretroviral therapy(ART)drugs on blood safety among blood donors in Shenzhen.Methods High pressure liquid chromatography coupled with tandem mass spectrometry(HPLC-MS/MS)was used to measure ART drugs concentrations in the plasma of regular blood donors(negative control group,n=86)and anti-HIV positive individuals(experimental group,n=98,detected from approximately 440000 blood donors during 2019—2023).The baseline plasma concentrations of ART drugs in the negative control group were clarified,and the impact of ART drugs on blood safety was analyzed.Results The baseline concentrations of ART drugs were not detected in 86 samples of negative control group.Four positive ART drugs samples were detected in 1∶2 pooled plasma samples of 98 anti-HIV positive blood donors plasma in the resolution test.The ART positive rate of anti-HIV positive donors was 4.08%,with tenofovir,lamivudine and efavirenz detected in three blood donors and lamivudine,lopinavir,ritonavir and zidovudine detected in one blood donor.Conclusion ART drugs were found among anti-HIV positive blood donors in Shenzhen.Additional research is needed to investigate the motivation of these specific donors,so as to ascertain the groups most susceptible to potential risks,and guarantee blood safety.

关 键 词：无偿献血者 抗病毒治疗药物 HIV 检出率 血液安全 

分 类 号：R446[医药卫生—诊断学]