同种异体富血小板血浆治疗肠造口周围皮肤损伤的探讨--附2例报道  

Skin injury around enterostomy cured by allogeneic platelet-rich plasma:a report of two cases

作　　者：姚红林 齐清 王淑君 沈硕 栾建凤 叶向红 YAO Honglin;QI Qing;WANG Shujun;SHEN Shuo;LUAN Jianfeng;YE Xianghong(Research Institute of General Surgery,2.Department of Blood Transfusion;Eastern Theater Command General Hospital,Nanjing 210002,China.)

机构地区：[1]东部战区总医院全军普通外科研究所,江苏南京210002 [2]东部战区总医院输血医学科,江苏南京210002

出　　处：《中国输血杂志》2024年第2期209-213,共5页Chinese Journal of Blood Transfusion

基　　金：东部战区总医院院内课题(YYMS2021019,22LCZLXJS52)。

摘　　要：目的探讨同种异体富血小板血浆(platelet rich plasma,PRP)应用于肠造口周围皮肤损伤治疗的可行性。方法分析2例应用PRP治疗肠造口周围皮肤损伤患者的治疗及护理过程,并对使用的PRP进行血小板、细菌检测和5种生长因子检测。结合治疗难点与文献内容复习,探讨肠内营养支持治疗的同时予以同种异体PRP治疗肠造口周围损伤的临床治疗效果。结果患者在清洁肠造口周围皮肤后,予以每日1次PRP治疗5 d后调整为隔日1次,分别于15 d和18 d达到治愈。结论异体PRP是1种安全、有效的促进肠造口周围皮肤损伤的治疗方法,为临床治疗提供新的思路。Objective To investigate the feasibility of allogeneic platelet-rich plasma(PRP)for the treatment of skin injury around enterostomy.Methods The treatment process by PRP of 2 patients with skin injury around enterostomy was analyzed,and the PRP for each patient was tested with platelet count,bacteria and 5 growth factors.The clinical efficacy of enteral nutrition support therapy combined with allogeneic PRP was explored through analyzing treatment key points and literature review.Results After cleaning the skin around enterostomy,the patients were treated with PRP once daily for 5 days,adjusted to once every other day,and cure was achieved at 15 and 18 days,respectively.Conclusion Allogeneic PRP is a safe and effective treatment to promote skin injury around enterostomy regeneration in a short time,which can provide a new perspective for clinical.

关 键 词：富血小板血浆 肠造口 造口周围皮肤损伤 

分 类 号：R457.14[医药卫生—治疗学] R619.5[医药卫生—临床医学]