血浆置换在重症免疫相关性皮肤病中的应用进展  

Progress in plasma exchange for severe immune-related dermatoses

作　　者：钟瑶 夏荣 ZHONG Yao;XIA Rong(Department of Transfusion,Affiliated Huashan Hospital of Fudan University,Shanghai 200040,China.)

机构地区：[1]复旦大学附属华山医院输血科,上海200040

出　　处：《中国输血杂志》2024年第2期244-248,共5页Chinese Journal of Blood Transfusion

基　　金：国家自然科学基金面上项目(82070197)。

摘　　要：血浆置换(plasma exchange, PE)在部分自身免疫性疾病中疗效肯定。PE主要的作用机制包括去除患者血液中的致病因子,调节患者免疫功能,补充正常的血浆成分等。在对寻常型天疱疮、中毒性表皮松解综合症和临床无肌病性皮肌炎等重症免疫相关性皮肤病的治疗中,PE的应用愈加广泛。本篇综述就近年来PE在国内外重症免疫相关性皮肤病中的应用进展做一概述,为临床重症皮肤病的治疗提供新思路。Plasma exchange(PE)is effective in a part of autoimmune diseases,and its main action mechanisms include removing pathogenic factors from the patient's blood,regulating immune function,replenishing normal plasma components.The use of PE in the treatment of severe immune-related skin diseases,such as pemphigus vulgaris,toxic epidermal necrolysis and clinically amyopathic dermatomyositis,has become more widespread.This review provides an overview of the progress of PE application in severe immune-related skin diseases at home and abroad in recent years to provide new ideas for the treatment of clinical severe skin diseases.

关 键 词：血浆置换 重症皮肤病 寻常型天疱疮 中毒性表皮松解综合症 临床无肌病性皮肌炎 

分 类 号：R457.14[医药卫生—治疗学] R751.05[医药卫生—临床医学]