原位自组装纳米递药系统用于肿瘤免疫治疗的研究进展  

Research progress of in-situ self-assembled nano-drug delivery systems for tumor immunotherapy

作　　者：刘欣欣 郑翠霞 牛梦亚 赵荦 王蕾[1,3] LIU Xinxin;ZHENG Cuixia;NIU Mengya;ZHAO Luo;WANG Lei(School of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou 450001,China;Translational Medicine Center,Huaihe Hospital of Henan University,Kaifeng 475000,China;Tumor Immunity and Biomaterials Advanced Medical Center,Luoyang Central Hospital Affiliated to Zhengzhou University,Luoyang 471009,China)

机构地区：[1]郑州大学药学院,河南郑州450001 [2]河南大学淮河医院转化医学中心,河南开封475000 [3]郑州大学附属洛阳中心医院郑州大学肿瘤免疫与生物材料先进医学研究中心,河南洛阳471009

出　　处：《沈阳药科大学学报》2024年第1期1-12,54,共13页Journal of Shenyang Pharmaceutical University

基　　金：国家自然科学基金资助项目(82272847);中原科技创新领军人才项目(234200510005);河南省优势学科培育联合基金重点项目(222301420012);河洛青年人才托举工程项目(2022HLTJ05)。

摘　　要：目的对原位自组装纳米递药系统的构建及其在肿瘤免疫治疗中的作用机制进行综述,旨在为基于肿瘤免疫治疗的药物递送提供新的思路。方法以“原位自组装”、“免疫治疗”、“肿瘤”等检索词对国内外文献进行查阅,总结自组装纳米递药系统在肿瘤部位的构建情况,并对其增强免疫疗效的机制进行归纳。结果原位自组装纳米递药系统能够通过体外辅助靶向到达病灶部位,在疏水相互作用、静电作用、配位键等多种作用力的驱动下,触发体外刺激或体内生理病理环境刺激进而原位自组装形成新的物质。该策略能够通过增加免疫药物滞留、提高肿瘤免疫原性、促进抗原呈递细胞的成熟以及增加免疫效应细胞浸润来增强机体免疫,综合提高免疫效力。结论今后应深度挖掘原位自组装纳米药物在抗肿瘤药物递送方面的意义,促使自组装药物在肿瘤治疗方面取得更大的进展。Objective The construction of in-situ self-assembled nano-drug delivery systems and their mechanism in tumor immunotherapy have been reviewed,aiming to provide new ideas for drug delivery based on tumor immunotherapy.Methods The terms"in-situ self-assembly","immunotherapy"and"tumor"are used to search for domestic and foreign literature,with the aim of summarizing the construction of tumor sites in self-assembled nano-drug delivery systems and their mechanisms for enhancing immune efficacy.Results In-situ self-assembled nano-drug delivery systems could reach the lesion site through in vitro assisted targeting.Driven by various forces such as hydrophobic interactions,electrostatic interactions,coordination bonds etc.,stimuli from in vitro or in vivo physiological and pathological environment could trigger in-situ self-assemble to form new substances.The body′s immunity could be improved comprehensively by increasing immune drug retention,enhancing tumor immunogenicity,promoting the maturation of antigen presenting cells or increasing immune effector cell infiltration.Conclusion In the future,the significance of in-situ self-assembled nanomedicine in the delivery of anti-tumor drugs should be deeply explored,promoting greater progress in self-assembled drugs in tumor treatment.

关 键 词：肿瘤 原位自组装 纳米递药系统 免疫治疗 肿瘤微环境 

分 类 号：R94[医药卫生—药剂学]