忍冬属植物中咖啡酰奎宁酸类成分及其吸收与代谢研究进展  

Research progress on caffeoylquinic acids in Lonicera L.and their absorption and metabolism

作　　者：田海涛 张喆[1] 赵盼[1] 李静[1] 张四喜[2] 邓志鹏 TIAN Haitao;ZHANG Zhe;ZHAO Pan;LI Jing;ZHANG Sixi;DENG Zhipeng(Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Department of Pharmacy,The First Hospital of Jilin University,Changchun 130021,China)

机构地区：[1]山东中医药大学,山东济南250355 [2]吉林大学第一医院药学部,吉林长春130021

出　　处：《药学研究》2024年第1期74-82,共9页Journal of Pharmaceutical Research

基　　金：山东省自然科学基金-面上项目(No.ZR2019MH051);山东省中医药科技项目(No.M-2023191);山东省医药卫生科技发展计划项目(No.202213030509)。

摘　　要：迄今为止从忍冬属植物中分离出24种咖啡酰奎宁酸类化合物,此类化合物显示有多种药理活性,具备广阔的应用前景,吸收与代谢研究发现其主要吸收部位为小肠,以被动扩散为主,代谢部位主要在大肠,代谢途径有甲基化、葡萄糖醛酸结合、水解、异构化和还原反应等。本文对忍冬属植物中咖啡酰奎宁酸类成分及其吸收与代谢研究进行总结,以期为咖啡酰基奎宁酸类药物研究开发提供参考。Caffeoylquinic acids are very important natural products with a variety of pharmacological activities and broad research prospects.By retrieving related literature,it was reported that 24 caffeoylquinic acids have been isolated from Lonicera L.so far.Absorption and metabolism research found that the main absorption site of caffeoylquinic acids is the small intestine,with passive diffusion as the main site,and the metabolic site is mainly in the large intestine.The metabolic pathways include methylation,glucuronidation,hydrolysis,isomerization and reduction reactions.This paper summarizes the chemical structures of caffeoylquinic acids in Lonicera L.and their absorption and metabolism,in order to provide reference for the research and development of caffeoylquinic acids.

关 键 词：忍冬属 咖啡酰奎宁酸 吸收与代谢 研究进展 

分 类 号：R285[医药卫生—中药学]