计算机辅助测量颈动脉周围脂肪密度与颈动脉斑块的关系  

Computer-aided measurement of carotid periarterial fat density in relation to carotid plaque

作　　者：王重阳 张林波 郭爽 丁娟 WANG Chongyang;ZHANG Linbo;GUO Shuang;DING Juan(Department of Radiology,The 964th Hospital of the PLA Joint Logistics Support Force,Changchun 130021,China;Department of Radiology,The 960th Hospital of the PLA Joint Logistics Support Force,Jinan 250031,China)

机构地区：[1]中国人民解放军联勤保障部队第九六四医院放射诊断科,吉林长春130021 [2]中国人民解放军联勤保障部队第九六〇医院放射诊断科,山东济南250031

出　　处：《医学影像学杂志》2024年第1期14-17,共4页Journal of Medical Imaging

基　　金：山东省自然科学基金项目(编号:ZR2012HQ007)。

摘　　要：目的探讨颈动脉周围脂肪密度与颈动脉斑块的关系。方法选取60例颈动脉粥样硬化患者的CTA图像分析,判断颈动脉粥样硬化斑块位置,利用计算机软件自动识别并测量颈动脉血管周围脂肪密度(PFD),比较颈动脉斑块PFD与对侧正常颈动脉PFD及同侧正常颈动脉PFD,比较双侧正常颈动脉PFD。分析PFD与斑块厚度、钙化斑块、狭窄程度的关系。绘制受试者工作特征(ROC)曲线,并计算曲线下面积(AUC)。结果颈动脉斑块PFD高于对侧及同侧正常颈动脉PFD(-58.61±11.52)HU、(-66.05±11.81)HU,差异有统计学意义(P<0.001)、(-58.82±12.75)HU、(-66.70±13.84)HU,差异有统计学意义(P<0.001)。对侧正常颈动脉PFD与同侧正常颈动脉PFD比较差异无统计学意义(-66.91HU±11.69)HU、(-66.37±16.06)HU,(P=0.806)。颈动脉斑块厚度与PFD比较差异有统计学意义(P=0.045)。组间斑块是否含有钙化、狭窄程度比较差异均无统计学意义,分别为(P=0.571、P=0.749)。根据PFD诊断斑块存在的AUC为0.645,敏感度和特异度分别为45.80%、78.00%。结论采用计算机辅助识别并测量颈动脉PFD,数据显示颈动脉斑块PFD明显增加,推测其与血管局部炎性反应相关。Objective To investigate the relationship between perivascular fat density(PFD)of carotid artery and plaque.Methods A retrospective analysis of CT angiography(CTA)images of carotid atherosclerosis was performed.After determining the location of the carotid atherosclerotic plaque,the carotid PFD was automatically identified and measured using computer software.The PFD of carotid plaque was compared with the PFD of the contralateral non-stenotic carotid artery and the PFD of the ipsilateral non-stenotic carotid artery.The PFD of bilateral non-stenotic carotid arteries was also compared.The relationship between PFD and plaque thickness,calcified plaque,and degree of stenosis was analyzed.The receiver operating characteristic(ROC)curves were drawn,and the areas under the curves(AUC)were calculated.Results PFD of carotid plaque was significantly higher than that of the contralateral non-stenotic carotid artery(-58.61±11.52HU and-66.05±11.81HU,P<0.001).It was also higher than that of ipsilateral non-stenotic carotid(-58.82±12.75HU and-66.70±13.84HU,P<0.001).No statistically significant difference was found between contralateral normal carotid PFD and ipsilateral normal carotid PFD for carotid plaque(-66.91HU±11.69HU and-66.37±16.06HU,P=0.806).The difference between carotid plaque thickness and PFD was statistically significant,P=0.045.There was no significant difference of whether the plaque contained calcification and the degree of stenosis,P=0.571 and 0.749.The AUC of PFD was 0.645,sensitivity was 45.8%,and specificity was 78%.Conclusion In this study,computer-aided identification and measurement of PFD of carotid arteries was used,and the results showed a significant increase in PFD of carotid plaque,which was presumed the asociation with a localized inflammatory response in the vasculature.

关 键 词：动脉粥样硬化 对比剂 血管周围脂肪密度 体层摄影术 X线计算机 

分 类 号：R543.4[医药卫生—心血管疾病] R814.42[医药卫生—内科学]