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作 者:司晓伟 肖靖 SI Xiaowei;XIAO Jing(Ningxia Hui Autonomous Region Hospital and Research Institute of Traditional Chinese Medicine,Yinchuan 750021,China)
机构地区:[1]宁夏回族自治区中医医院暨中医研究院,银川750021
出 处:《宁夏医科大学学报》2023年第12期1238-1241,共4页Journal of Ningxia Medical University
基 金:宁夏医科大学科学研究基金资助项目(XM2020069)。
摘 要:目的观察平喘颗粒对儿童咳嗽变异性哮喘(风热袭肺证)的临床疗效。方法研究对象为2021年1月至2022年11月在宁夏回族自治区中医医院暨中医研究院就诊的60例符合中、西医临床诊断标准及纳入与排除标准的咳嗽变异性哮喘患儿(证型为风热袭肺证),按照随机数表法分为治疗组和对照组,每组30例。治疗组口服平喘颗粒治疗,对照组口服孟鲁司特钠咀嚼片治疗,两组均干预2周后,比较两组治疗前后总体疗效、中医证候积分、肺功能相关指标及血清总免疫球蛋白(IgE)水平变化。结果治疗后,治疗组总有效率(96.67%)高于对照组(83.33%),中医证候积分低于对照组(P均<0.05)。与治疗前比较,治疗后两组患儿用力肺活量(FVC)、最大呼气流量(PEF)、第1秒用力呼气容积(FEV1)和血清总IgE水平均得到改善(P均<0.05),且治疗组上述各指标改善程度均优于对照组(P均<0.05)。在安全性方面,两组患者均未出现明显毒副作用。结论平喘颗粒可能通过减少血清总IgE水平改善儿童咳嗽变异性哮喘发作期风热袭肺证临床症状并改善肺通气功能。Objective To observe the clinical effect of Pingchuan Granule on cough variant asthma(wind-heat attacking lung syndrome)in children.Methods The subjects of the study were 60 children with cough variant asthma(wind-heat attacking lung syndrome)who met the clinical diagnostic criteria and inclusion and exclusion criteria from January 2021 to November 2022 in Ningxia Hui Autonomous Region Hospital and Research Institute of Traditional Chinese Medicine.The randomized controlled study was used to divided the treatment group and the control group,with 30 cases in each group.The treatment group was treated with Pingchuan Granule orally,while the control group was treated with Montelukast Sodium Chewable Tablets orally.After 2 weeks of intervention,the overall efficacy,TCM syndrome score,lung function related indexes and serum total IgE level of the two groups were analyzed before and after treatment.Results After treatment,the total effective rate of the treatment group(96.67%)was higher than that of the control group(83.33%),and the TCM syndrome score was lower than the control group(P all<0.05).Compared with before treatment,FVC,PEF,FEV1 and serum total IgE in the two groups were improved after treatment(P all<0.05),and the improvement of each index in the treatment group were better than that in the control group(P all<0.05).In terms of safety,two groups of patients showed no significant side effects.Conclusion Pingchuan Granule may improve the clinical symptoms of wind-heat attacking lung syndrome and improve lung ventilation function in children with cough variant asthma by reducing serum total IgE levels.
分 类 号:R272[医药卫生—中医儿科学]
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