糖尿病合并非酒精性脂肪性肝病发病机制及诊疗研究进展  

Research Progress on Pathogenesis,Diagnosis and Treatment of Diabetes Mellitus Complicated with Non-alcoholic Fatty Liver Disease

作　　者：邓娜 郭志新[1] DENG Na;GUO Zhixin(Department of Endocrinology,The Second Clinical Medical College of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第二临床医学院内分泌科,太原030001

出　　处：《宁夏医科大学学报》2023年第12期1279-1284,共6页Journal of Ningxia Medical University

基　　金：山西省国际科技合作项目(201703D421032);山西省回国留学人员科研资助项目(2020-192)。

摘　　要：糖尿病(DM)是一种自身免疫性代谢性疾病,与遗传及环境因素相关,其特点为因胰岛素抵抗或胰岛素相对缺少所引起的持续高血糖状态。持续高血糖状态易并发眼、肾脏、神经、心肌等组织器官的慢性病变、功能下降和衰竭。长期高血糖引起的各种慢性并发症是糖尿病患者死亡的主要原因,而非酒精性脂肪性肝病(NAFLD)是长期高血糖患者常出现在肝功能方面的严重并发症,其发生率逐渐升高,且2型糖尿病(T2DM)合并NAFLD患者病情更易进展,严重影响患者健康。因此,应对所有DM患者进行早期NAFLD的筛查,以明确诊断并进行适当的治疗,从而减缓脂肪性肝炎、肝硬化和肝癌等相关疾病的发生和发展。Diabetes mellitus(DM)is an autoimmune metabolic disease related to genetic and environmental factors.It is characterized by persistent hyperglycemia caused by insulin resistance or relative lack of insulin,which is easily complicated with chronic pathological changes of the organs such as eyes,kidneys,nerves and myocardium long-term high blood sugar caused by all kinds of chronic complications are the leading cause of death in diabetic patients,and non-alcoholic fatty liver disease(NAFLD)is a long-term high blood sugar patients often appear in the severe complication of liver function,its incidence rate gradually increases,and the merger of T2DM with NAFLD patients are more likely to progress.Therefore,early screening of NAFLD should be carried out for all DM patients to clarify the diagnosis and provide appropriate treatment,thereby slowing down the occurrence and development of related diseases such as steatohepatitis,cirrhosis,and liver cancer.

关 键 词：糖尿病 非酒精性脂肪性肝病 发病机制 诊断 治疗 

分 类 号：R285.5[医药卫生—中药学] R575.5[医药卫生—中医学]