大理地区慢性光化性皮炎患者最小红斑量和光斑贴试验分析  

Analysis of Minimal Erythema Dose and Photopatch Test in Patients with Chronic Actinic Dermatitis in Dali Region

作　　者：杨成林 胡婕 王静[3] 黄玲 王敏华 Yang Chenglin;Hu Jie;Wang Jing;Huang Ling;Wang Minhua(Dali Nursing Vocational College,Dali,Yunnan 671000,China;Lu′an Hospital of Traditional Chinese Medicine,Lu′an,Anhui 237000,China;Jinshan Hospital of Fudan University,Shanghai 200540,China;The First Affiliated Hospital of Dali University,Dali,Yunnan 671000,China)

机构地区：[1]大理护理职业学院,云南大理671000 [2]六安市中医医院,安徽六安237000 [3]复旦大学附属金山医院,上海200540 [4]大理大学第一附属医院,云南大理671000

出　　处：《大理大学学报》2024年第2期51-54,共4页Journal of Dali University

基　　金：云南省教育厅科学研究基金项目(2015Y382,2018Y151)。

摘　　要：目的:检测大理地区慢性光化性皮炎(CAD)患者最小红斑量(MED)及光斑贴试验,探讨CAD患者致病光谱差异及可能的致敏物质。方法:采用日光模拟器对25例CAD患者和20例健康志愿者进行MED检测,应用瑞敏标准光斑贴试剂盒进行光斑贴试验。结果:CAD患者的长波紫外线最小红斑量(UVA-MED)为25.63 J/cm^(2),中波紫外线最小红斑量(UVB-MED)为20.56mJ/cm^(2),健康志愿者UVA-MED为49.92 J/cm^(2),UVB-MED为38.80 mJ/cm^(2),CAD患者和健康志愿者相比MED值均显著降低(P<0.05);CAD患者光斑贴试验阳性率为44%,常见的光变应原为:2-(4-二乙氨基-2-羟基苯甲酰基)-苯甲酸己酯、盐酸异丙嗪和2-羟基-4-甲氧基苯酮。结论:CAD患者对UVA、UVB均敏感,光接触变应原的暴露可能是CAD的诱发因素。Objective:To investigate the minimal erythema dose(MED)and photopatch test in patients with chronic actinic dermatitis(CAD)in Dali region,aiming to explore the differences in the pathogenic spectrum of CAD patients and potential sensitizing substances.Methods:MED was measured using a solar simulator in 25 CAD patients and 20 healthy volunteers.The photopatch test was conducted using the RIMIN standard photopatch test reagent kit.Results:The long-wave ultraviolet minimal erythema dose(UVAMED)for CAD patients was 25.63 J/cm^(2),and the medium-wave ultraviolet minimal erythema dose(UVB-MED)was 20.56 mJ/cm^(2).The UVA-MED for healthy volunteers was 49.92 J/cm^(2),and the UVB-MED was 38.80 mJ/cm^(2).The MED values in CAD patients were significantly lower compared to healthy volunteers(P<0.05).The positive rate of photopatch test in CAD patients was 44%,with common photoallergens including hexyl 2-(4-diethylamino-2-hydroxybenzoyl)benzoate,promethazine hydrochloride,and 2-hydroxy-4-methoxybenzophenone.Conclusion:CAD patients are sensitive to both UVA and UVB,and exposure to photocontact allergens may be an inducing factor for CAD.

关 键 词：慢性光化性皮炎 最小红斑量 光斑贴试验 

分 类 号：R758.14[医药卫生—皮肤病学与性病学]