细胞焦亡与肺动脉高压的关系及治疗肺动脉高压药物研究进展  

Advances in relationship between pyroptosis and pulmonary arterial hypertension and therapeutic drugs

作　　者：颜倩 孙洋 龙俊鹏 刘莎莎 姚娇 林玉婷 阳松威 杨岩涛[1,2] 裴刚 艾启迪[1,2] 陈乃宏 YAN Qian;SUN Yang;LONG Jun-peng;LIU Sha-sha;YAO Jiao;LIN Yu-ting;YANG Song-wei;YANG Yan-tao;PEI Gang;AI Qi-di;CHEN Nai-hong(College of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,China;Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces,Changsha 410208,China;Xiangtan Central Hospital,Xiangtan Hunan 411199,China;Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)

机构地区：[1]湖南中医药大学药学院,湖南长沙410208 [2]湖南省中药饮片标准化及功能工程技术研究中心,湖南长沙410208 [3]湘潭市中心医院,湖南湘潭411199 [4]中国医学科学院药物研究所,北京协和医学院药物研究所,北京100050

出　　处：《中国药理学通报》2024年第1期25-30,共6页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 82174271);湖南省自然科学基金项目(No 2021JJ30512,2022JJ40456,2022JJ40313);湖南省科技厅优秀青年项目(No 21B0354);长沙市自然科学基金(No kq2202269,kq2014091);湖南中医药大学生物工程重点学科([2018] No 3);湖南中医药大学中药学一流学科建设项目。

摘　　要：细胞焦亡(pyroptosis)是指伴有炎性反应的一种细胞程序性死亡方式,其广泛参与了多种疾病的发生发展,例如感染性疾病、心血管疾病和神经性退行等。研究表明,细胞焦亡参与了心血管疾病中动脉性肺动脉高压(pulmonary arterial hypertension, PAH)的发病机制。PAH患者的肺部存在血管周围炎症浸润,肺血管病变存在于极度发炎的微环境里,细胞焦亡中的促炎因子驱动了PAH患者的肺部血管重塑。本文针对细胞焦亡在PAH发病机制中的作用及治疗PAH药物的相关研究进行综述,旨在为临床上治疗PAH提供新思路。Pyroptosis is the programmed death of cells accompanied by an inflammatory response and is widely involved in the development of a variety of diseases,such as infectious diseases,cardiovascular diseases,and neurodegeneration.It has been shown that cellular scorching is involved in the pathogenesis of pulmonary arterial hypertension(PAH)in cardiovascular diseases.Patients with PAH have perivascular inflammatory infiltrates in lungs,pulmonary vasculopathy exists in an extremely inflammatory microenvironment,and pro-inflammatory factors in cellular scorching drive pulmonary vascular remodelling in PAH patients.This article reviews the role of cellular scorch in the pathogenesis of PAH and the related research on drugs for the treatment of PAH,with the aim of providing new ideas for clinical treatment of PAH.

关 键 词：细胞焦亡 动脉性肺动脉高压 肺动脉高压 治疗药物 炎症小体 发病机制 

分 类 号：R322.121[医药卫生—人体解剖和组织胚胎学] R364.5[医药卫生—基础医学] R394.2R544