超疏水表面在抗/促凝血领域的研究进展  

Research progress of superhydrophobic surfaces inthe field of anti/procoagulant

作　　者：关小雅 吴兵[1] 彭毅[1] GUAN Xiaoya;WU Bing;PENG Yi(School of Mechanical Engineering,Guizhou University,Guiyang 550025,China)

机构地区：[1]贵州大学机械工程学院,贵阳550025

出　　处：《功能材料》2024年第1期1068-1076,共9页Journal of Functional Materials

基　　金：国家自然科学基金项目(52065011);贵州省教育厅项目(黔教合KY字[2021]058)。

摘　　要：近年来,随着超疏水材料在冷凝传热、油水分离、除冰防雾、表面防腐、管道减阻等方面应用的研究逐步趋于成熟,其在生物医疗领域的应用前景也备受学者关注,由于医疗设备与血液接触时产生的凝血血栓及大量出血引发的失血性休克问题会对患者生命安全造成极大威胁。为了能够有效解决血栓出现及大量失血问题,国内外诸多学者展开了大量研究,超疏水材料由于其特殊的表面润湿性及较低的表面自由能可显著降低材料表面的血小板粘附量,其与亲水材料的组合可在止血的前提下减少出血量并降低伤口二次撕裂出血的可能,同时,研究表明超疏水材料还具有良好的抗菌性,故针对超疏水材料的研究成为了该领域的热点与方向。基于此,首先介绍了超疏水材料基本理论,主要包括Young润湿模型、Wenzel润湿模型以及Cassie-Baxter润湿模型,其次详细阐述了其在抗/促凝血过程中的作用机理,然后以部分研究为代表着重讨论了目前超疏水材料在血液接触应用领域的研究现状,指明超疏水材料在该领域的应用中主要存在的问题,最后对其未来的发展前景进行了展望。In recent years,with the research on the application of superhydrophobic materials in condensation heat transfer,oil-water separation,deicing and anti-fogging,surface corrosion prevention,pipeline resistance reduction and other aspects gradually becoming mature.The application prospect of superhydrophobic materials in the biomedical field has also attracted the attention of scholars.Coagulation thrombus and hemorrhagic shock caused by massive hemorrhage when medical equipment contacts with blood will pose great threat to the life safety of patients.In order to effectively solve that problems of thrombus occurrence and massive blood loss,many scholars at home and abroad have carried out a great deal of research.Due to the special surface wettability and lower surface free energy of the super-hydrophobic material,the platelet adhesion amount on the surface of the material can be significantly reduced.The combination of the super-hydrophobic material and hydrophilic material can reduce the bleeding amount and the possibility of secondary laceration bleeding of a wound on the premise of hemostasis.Meanwhile,the research shows that the super-hydrophobic material also has good antibacterial property.Therefore,the research on superhydrophobic materials has become a hot spot and direction in this field.Based on this,this paper first introduces the basic theory of superhydrophobic surfaces,mainly including the Young wetting model,Wenzel wetting model and Cassie-Baxter wetting model,then the mechanism of superhydrophobic materials in the process of anti-coagulation and pro-coagulation is expounded in detail.The current research status of superhydrophobic materials in the field of blood contact is discussed,and the main problems in the application of superhydrophobic materials in this field are pointed out.Finally,the future development of superhydrophobic materials is prospected.

关 键 词：超疏水 润湿性 抗/促凝血 血小板粘附 抗菌性 

分 类 号：TB174[生物学—生物工程]