排石汤对草酸钙泌尿系结石患者尿液成分的影响  

Effect of Paishi Decoction on urine composition of patients with calcium oxalate urinary calculi

作　　者：张海旺 张洪海 田泽阳 张立 Zhang Haiwang;Zhang Honghai;Tian Zeyang;Zhang Li(Department of Surgery,Shunyi Hospital,Beijing Hospital of Traditional Chinese Medicine,Beijing 101300,China)

机构地区：[1]北京中医医院顺义医院外科,北京101300

出　　处：《国际泌尿系统杂志》2024年第1期98-101,共4页International Journal of Urology and Nephrology

基　　金：北京中医医院顺义医院院级临床课题(SYYJLC-202203)。

摘　　要：目的探讨排石汤对经尿道输尿管镜碎石术(URL)后草酸钙泌尿系结石患者尿骨桥蛋白(OPN)、尿钙、尿草酸钙的影响。方法选取2018年6月至2022年6月在本院收治的80例草酸钙泌尿系结石患者, 随机分为对照组(40例)和观察组(40例)。观察组服用排石汤, 连用3个疗程;对照组给予同等量安慰剂(5%排石汤及食用色素组成)。分别检测两组患者术前、术后第1、7、14、21、28天的尿OPN、尿钙、尿草酸钙含量。结果与术前比较, 术后第7、14、21、28天两组的尿OPN含量均呈上升趋势, 尿钙、尿草酸钙含量均呈下降趋势, 差异均有统计学意义(均P<0.05);但术后第1天与术前比较, 两组的尿OPN、尿钙、尿草酸钙含量比较, 差异均无统计学意义(均P>0.05);而术后第7、14、21、28天, 观察组的尿OPN含量均高于对照组, 尿钙、尿草酸钙含量均低于对照组(均P<0.05)。结论草酸钙泌尿系结石患者URL术后应用排石汤, 对提高尿OPN含量及降低尿钙、尿草酸钙含量有明显帮助。Objective To explore the effect of Paishi Decoction on urinary osteopontin(OPN),urinary calcium and urinary calcium oxalate in patients with calcium oxalate urinary calculi after transurethral ureteroscopy(URL).Methods A total of 80 patients with calcium oxalate urinary calculi treated in our hospital from June 2018 to June 2022 were randomly divided into control group(40 cases)and observation group(40 cases).The observation group took Paishi Decoction for 3 consecutive courses,the control group was given the same amount of placebo(5%Paishi Decoction and edible pigment).The contents of urinary OPN,urinary calcium and urinary calcium oxalate in the two groups were measured before operation and on the 1st,7th,14th,21st and 28th day after operation.Results Compared with that before operation,the urinary OPN of patients in the observation group and the control group showed an upward trend on the 7th,14th,21st and 28th day after operation,and the urinary calcium and urinary calcium oxalate showed a downward trend,the difference was statistically significant(all P<0.05).However,there was no significant difference between the indexes on the first day after operation and those before operation(all P>0.05).On the 7th,14th,21st and 28th day after operation,the urinary OPN of the observation group was higher than that of the control group,and the urinary calcium and urinary calcium oxalate were lower than that of the control group(all P<0.05).The application of Paishi Decoction after URL in patients with calcium oxalate urinary calculi can significantly help to increase the content of urinary OPN and reduce the content of urinur-Conclusions inary calcium and urinary calcium oxalate.

关 键 词：草酸钙 泌尿系结石 排石汤 尿液 

分 类 号：R277.5[医药卫生—中医学]