丰富的环境干预在母婴分离模型中的作用  

Role of enriched environment in the model of maternal separation

作　　者：李继承 姜敏 黑明燕 LI Jicheng;JIANG Min;HEI Mingyan(Neonatal Center,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing 100045,China)

机构地区：[1]国家儿童医学中心首都医科大学附属北京儿童医院新生儿中心,北京100045

出　　处：《中国儿童保健杂志》2024年第2期164-168,共5页Chinese Journal of Child Health Care

基　　金：国家自然科学基金面上项目(82371712)。

摘　　要：人类早期生活应激可以影响个体神经元网络的正常发育,最终可能导致该类患儿罹患焦虑症、抑郁症、自闭症等疾病。啮齿类动物母婴分离模型是模拟人类出生早期不良经历的应激模型之一,研究表明与母鼠分离可以使幼鼠在成年期出现焦虑、抑郁、空间学习和记忆能力受损等表现。而丰富环境干预可以通过一系列的积极影响来改善早期生活应激所带来的不良后果,本文就丰富环境干预对于母鼠分离模型中小鼠的改善作用进行总结。Early life stress in humans can affect the normal development of individual neural networks, ultimately leading to diseases such as anxiety, depression, and autism in such children. The maternal separation model is commonly used to study the effects of early adverse experiences in human infants. Studies have shown that maternal separation in mice can lead to anxiety, depression, and impairments in spatial learning and memory in young mice during adulthood. However, enriched environmental interventions have been found to ameliorate the negative outcomes of early life stress by exerting a range of beneficial effects. This article provides an overview of the positive effects of enriched environmental interventions on mice in the maternal separation model.

关 键 词：应激 母婴分离 丰富的环境 

分 类 号：R72[医药卫生—儿科] R-332[医药卫生—临床医学]