前体离子扫描超高效液相色谱-三重四级杆串联质谱法快速筛查化妆品中非法添加的磺胺类药物  

Screening for illegal addition of sulfonamides in cosmetic products using ultra-performance liquid chromatographytriple quadrupoletandem mass spectrometry with precursor ion scanning

作　　者：芦丽 方方 冯有龙 曹玲 Li Lu;Fang Fang;Youlong Feng;Ling Cao(Jiangsu Institute for Food and Drug Control,Nanjing,Jiangsu 210008,China)

机构地区：[1]江苏省食品药品监督检验研究院,江苏南京210008

出　　处：《日用化学工业（中英文）》2024年第2期216-223,共8页China Surfactant Detergent & Cosmetics

基　　金：江苏省市场监督管理局科技计划项目(KJ207560)。

摘　　要：磺胺类药物(SAs)为化妆品中禁用物质。采用超高效液相色谱-三重四级杆/复合线性离子阱串联质谱(UPLCQTrap),利用前体离子-增强子离子扫描(PIS-IDA-EPI)模式,用于快速筛查化妆品中非法添加的SAs。选择三个碰撞诱导解离形成的产物离子m/z 92,m/z 108,m/z 156,对12种化妆品基质中的20个SAs进行PIS-IDA-EPI扫描分析,检出限LODs为0.05~0.1μg/g,该方法在12批次化妆品加标样品中进行了验证,并测定了60批次化妆品样品,以确保其有效性、灵敏度和选择性。实验结果表明:UPLC-QTrap结合PIS-IDA-EPI采集模式是一种有效的筛查方法,并成功应用于化妆品样品中目标和非目标SAs的快速筛查。Sulfonamides(SAs)are prohibited substances in cosmetics.An ultra-performance liquid chromatographytriple quadrupole tandem mass spectrometry(UPLC-QTrap)method using precursor ion-information dependent acquisition-enhanced product ion(PIS-IDA-EPI)scanning mode was developed to screen SAs in cosmetics.Twenty SAs were investigated to identify their common product ions formed by collision-induced dissociation.Three common positive product ions,m/z 92,m/z 108,m/z 156 are selected for PIS analysis.Limits of detection(LODs)are 0.05-0.1μg/g for all 20 SAs in 12 kinds of cosmetic matrix.Sixty samples are analyzed.An effective screening method using UPLC-QTrap with PIS-IDA-EPI acquisition mode is developed and successfully applied to screen for the targeted and untargeted SAs in cosmetic samples.

关 键 词：磺胺类药物 化妆品 三重四级杆/复合线性离子阱质谱(QTrap) 前体离子扫描(PIS) 

分 类 号：TQ658[化学工程—精细化工]