中药干预线粒体自噬治疗糖尿病肾病研究进展  

Research progress of traditional Chinese medicine intervention on mitochondrial autophagy in the treatment of diabetic kidney disease

作　　者：魏金凤 魏晓涛 王彩红 王威威 张新丽[3] 何志军[3] 刘涛 WEI Jinfeng;WEI Xiaotao;WANG Caihong;WANG Weiwei;ZHANG Xinli;HE Zhijun;LIU Tao(Special Needs Ward,Jiu Gang Hospital,Jiayuguan 735100,Gansu Province,China;Clinical College of Chinese Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China;Department of Nephrology,Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]酒钢医院特需病区,甘肃嘉峪关735100 [2]甘肃中医药大学中医临床学院,兰州730000 [3]甘肃省中医院肾病科,兰州730000

出　　处：《数理医药学杂志》2024年第2期136-143,共8页Journal of Mathematical Medicine

基　　金：甘肃省中医药管理局重点课题(GZKG-2022-3)。

摘　　要：糖尿病肾病(diabetic kidney disease,DKD)作为最常见的糖尿病肾脏系统微血管病变,是慢性肾脏病和终末期肾病的主要发病因素。DKD主要临床特征为肾小球高滤过和蛋白尿、血肌酐、尿素氮、进行性增加的肾功能异常改变,主要病理改变为后期肾小球硬化和肾小管间质纤维化。DKD发病机制复杂,线粒体可通过干预DKD发病,参与晚期糖基化终末产物的产生、活性氧物种、内质网应激、炎症因子和肾素血管紧张素系统的激活,在DKD发生发展中发挥关键作用。中药提取物及中药复方可通过干预PTEN诱导激酶1(Pink1)/E3泛素连接酶(Parkin)信号通路或有丝分裂受体通路,调控线粒体自噬,保护和恢复线粒体功能,起到预防、治疗和缓解DKD的作用。本文通过总结中药提取物及中药复方干预线粒体自噬相关介导信号通路表达治疗DKD的研究进展,以期为中药应用于DKD的防治提供参考。Diabetic kidney disease(DKD),as the most common microangiopathy of the diabetic renal system,is the main pathogenetic factor of chronic kidney disease and end-stage renal disease.DKD is clinically characterised by glomerular hyperfiltration and proteinuria,blood creatinine,urea nitrogen,and progressively increasing abnormal renal function,and the main pathological changes are dominated by advanced glomerulosclerosis and tubulointerstitial fibrosis.The pathogenesis of DKD is complex.Mitochondria can play a key role in the development of DKD by intervening in the pathogenesis of DKD and participating in the production of end products of advanced glycosylation,reactive oxygen species,endoplasmic reticulum stress,inflammatory factors,and the activation of renin-angiotensin system.Traditional Chinese medicine extracts and traditional Chinese medicine combinations can regulate mitochondrial autophagy,protect and restore mitochondrial function through the intervention of the PTEN-inducible kinase 1(Pink1)/E3 ubiquitin ligase(Parkin)signalling pathway or mitogenic receptor pathway,and play a role in the prevention,treatment and alleviation of DKD.This paper summarises the research progress of traditional Chinese medicine extracts and traditional Chinese medicine combinations interfering with the expression of mitochondrial autophagy-related mediated signaling pathway in the treatment of DKD,in order to provide reference for the application of traditional Chinese medicine in the prevention and treatment of DKD.

关 键 词：糖尿病肾病 线粒体 自噬 中药 

分 类 号：R285[医药卫生—中药学]